@article{5863b470894e48e68f32462030c397a9,
title = "Structure of Nampt/PBEF/visfatin, a mammalian NAD+ biosynthetic enzyme",
abstract = "Nicotinamide phosphoribosyltransferase (Nampt) synthesizes nicotinamide mononucleotide (NMN) from nicotinamide in a mammalian NAD+ biosynthetic pathway and is required for SirT1 activity in vivo. Nampt has also been presumed to be a cytokine (PBEF) or a hormone (visfatin). The crystal structure of Nampt in the presence and absence of NMN shows that Nampt is a dimeric type II phosphoribosyltransferase and provides insights into the enzymatic mechanism.",
author = "Tao Wang and Xiangbin Zhang and Poonam Bheda and Revollo, {Javier R.} and Imai, {Shin Ichiro} and Cynthia Wolberger",
note = "Funding Information: We thank the staff at GM/CA-CAT at the Advanced Photon Source, which is funded in part by the US National Cancer Institute (Y1-CO-1020) and the US National Institute of General Medical Sciences (Y1-GM-1104). J.R.R. is a fellow supported by the Lucille P. Markey Special Emphasis Pathway in Human Pathology. S.I. is an Ellison Medical Foundation Scholar in Aging.",
year = "2006",
month = jul,
doi = "10.1038/nsmb1114",
language = "English",
volume = "13",
pages = "661--662",
journal = "Nature Structural and Molecular Biology",
issn = "1545-9993",
number = "7",
}