Structure of a novel antimalarial gallium(III) complex with selective activity against chloroquine-resistant Plasmodium falciparum

Vijay Sharma; Alicia Beatty; Daniel E. Goldberg; David Piwnica-Worms

doi:10.1039/a705563c

Structure of a novel antimalarial gallium(III) complex with selective activity against chloroquine-resistant Plasmodium falciparum

Vijay Sharma, Alicia Beatty, Daniel E. Goldberg, David Piwnica-Worms

Research output: Contribution to journal › Article › peer-review

32 Scopus citations

Abstract

The crystal structure of an amine phenol complex of gallium(III), [{1,12-bis(2-hydroxy-3-methoxybenzyl)-1,5,8,12-tetraazadodecane}gallium(III)] [Ga(madd)]⁺, a potent new antimalarial which selectively targets chloroquine-resistant organisms is reported; the compound is shown to directly inhibit heme polymerization.

Original language	English
Pages (from-to)	2223-2224
Number of pages	2
Journal	Chemical Communications
Issue number	22
DOIs	https://doi.org/10.1039/a705563c
State	Published - 1997

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title = "Structure of a novel antimalarial gallium(III) complex with selective activity against chloroquine-resistant Plasmodium falciparum",

abstract = "The crystal structure of an amine phenol complex of gallium(III), [{1,12-bis(2-hydroxy-3-methoxybenzyl)-1,5,8,12-tetraazadodecane}gallium(III)] [Ga(madd)]+, a potent new antimalarial which selectively targets chloroquine-resistant organisms is reported; the compound is shown to directly inhibit heme polymerization.",

author = "Vijay Sharma and Alicia Beatty and Goldberg, {Daniel E.} and David Piwnica-Worms",

year = "1997",

doi = "10.1039/a705563c",

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pages = "2223--2224",

journal = "Chemical Communications",

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T1 - Structure of a novel antimalarial gallium(III) complex with selective activity against chloroquine-resistant Plasmodium falciparum

AU - Sharma, Vijay

AU - Beatty, Alicia

AU - Goldberg, Daniel E.

AU - Piwnica-Worms, David

PY - 1997

Y1 - 1997

N2 - The crystal structure of an amine phenol complex of gallium(III), [{1,12-bis(2-hydroxy-3-methoxybenzyl)-1,5,8,12-tetraazadodecane}gallium(III)] [Ga(madd)]+, a potent new antimalarial which selectively targets chloroquine-resistant organisms is reported; the compound is shown to directly inhibit heme polymerization.

AB - The crystal structure of an amine phenol complex of gallium(III), [{1,12-bis(2-hydroxy-3-methoxybenzyl)-1,5,8,12-tetraazadodecane}gallium(III)] [Ga(madd)]+, a potent new antimalarial which selectively targets chloroquine-resistant organisms is reported; the compound is shown to directly inhibit heme polymerization.

UR - http://www.scopus.com/inward/record.url?scp=0030663869&partnerID=8YFLogxK

U2 - 10.1039/a705563c

DO - 10.1039/a705563c

M3 - Article

AN - SCOPUS:0030663869

SN - 1359-7345

SP - 2223

EP - 2224

JO - Chemical Communications

JF - Chemical Communications

IS - 22

ER -

Structure of a novel antimalarial gallium(III) complex with selective activity against chloroquine-resistant Plasmodium falciparum

Abstract

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