Structure of a novel antimalarial gallium(III) complex with selective activity against chloroquine-resistant Plasmodium falciparum

Vijay Sharma, Alicia Beatty, Daniel E. Goldberg, David Piwnica-Worms

Research output: Contribution to journalArticlepeer-review

32 Scopus citations

Abstract

The crystal structure of an amine phenol complex of gallium(III), [{1,12-bis(2-hydroxy-3-methoxybenzyl)-1,5,8,12-tetraazadodecane}gallium(III)] [Ga(madd)]+, a potent new antimalarial which selectively targets chloroquine-resistant organisms is reported; the compound is shown to directly inhibit heme polymerization.

Original languageEnglish
Pages (from-to)2223-2224
Number of pages2
JournalChemical Communications
Issue number22
DOIs
StatePublished - 1997

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