Structure-function associations in hippocampus in bipolar disorder

Lara G. Chepenik, Fei Wang, Linda Spencer, Marisa Spann, Jessica H. Kalmar, Fay Womer, E. Kale Edmiston, Brian Pittman, Hilary P. Blumberg

Research output: Contribution to journalArticlepeer-review

35 Scopus citations


Hippocampus volume decreases and verbal memory deficits have been reported in bipolar disorder (BD) as independent observations. We investigated potential associations between these deficits in subjects with BD. Hippocampus volumes were measured on magnetic resonance images of 31 subjects with BD and 32 healthy comparison (HC) subjects. The California Verbal Learning Test-Second Edition (CVLT) assessed verbal memory function in these subjects. Compared to the HC group, the BD group showed both significantly smaller hippocampus volumes and impaired performance on CVLT tests of immediate, short delay and long delay cued and free recall. Further, smaller hippocampus volume correlated with impaired performance in BD. Post hoc analyses revealed a trend towards improved memory in BD subjects taking antidepressant medications. These results support associations between morphological changes in hippocampus structure in BD and verbal memory impairment. They provide preliminary evidence pharmacotherapy may reverse hippocampus-related memory deficits.

Original languageEnglish
Pages (from-to)18-22
Number of pages5
JournalBiological Psychology
Issue number1
StatePublished - Apr 2012


  • Bipolar disorder
  • CVLT
  • Hippocampus
  • Magnetic resonance imaging
  • Memory


Dive into the research topics of 'Structure-function associations in hippocampus in bipolar disorder'. Together they form a unique fingerprint.

Cite this