Structure-function associations in hippocampus in bipolar disorder

Lara G. Chepenik, Fei Wang, Linda Spencer, Marisa Spann, Jessica H. Kalmar, Fay Womer, E. Kale Edmiston, Brian Pittman, Hilary P. Blumberg

Research output: Contribution to journalArticle

24 Scopus citations

Abstract

Hippocampus volume decreases and verbal memory deficits have been reported in bipolar disorder (BD) as independent observations. We investigated potential associations between these deficits in subjects with BD. Hippocampus volumes were measured on magnetic resonance images of 31 subjects with BD and 32 healthy comparison (HC) subjects. The California Verbal Learning Test-Second Edition (CVLT) assessed verbal memory function in these subjects. Compared to the HC group, the BD group showed both significantly smaller hippocampus volumes and impaired performance on CVLT tests of immediate, short delay and long delay cued and free recall. Further, smaller hippocampus volume correlated with impaired performance in BD. Post hoc analyses revealed a trend towards improved memory in BD subjects taking antidepressant medications. These results support associations between morphological changes in hippocampus structure in BD and verbal memory impairment. They provide preliminary evidence pharmacotherapy may reverse hippocampus-related memory deficits.

Original languageEnglish
Pages (from-to)18-22
Number of pages5
JournalBiological Psychology
Volume90
Issue number1
DOIs
StatePublished - Apr 1 2012

Keywords

  • Bipolar disorder
  • CVLT
  • Hippocampus
  • Magnetic resonance imaging
  • Memory

Fingerprint Dive into the research topics of 'Structure-function associations in hippocampus in bipolar disorder'. Together they form a unique fingerprint.

  • Cite this

    Chepenik, L. G., Wang, F., Spencer, L., Spann, M., Kalmar, J. H., Womer, F., Kale Edmiston, E., Pittman, B., & Blumberg, H. P. (2012). Structure-function associations in hippocampus in bipolar disorder. Biological Psychology, 90(1), 18-22. https://doi.org/10.1016/j.biopsycho.2012.01.008