TY - JOUR
T1 - Structure, biologic properties, and expression of surfactant protein D (SP-D)
AU - Crouch, Erika C.
N1 - Funding Information:
I am grateful for a long and productive collaboration with Dr. Kevin Hartshorn that has led to a detailed understanding of the interactions of SP-D and other collectins with influenza A, and with Margot Anders, University of Melbourne, Australia for collaborative studies correlating interactions of SP-D with influenza A and viral multiplication in vivo. I also thank Janet North for excellent secretarial assistance. The personal studies cited in the review were supported by NIH Grants HL44015 and HL29594.
PY - 1998/11/19
Y1 - 1998/11/19
N2 - Surfactant protein D (SP-D) is a member of the family of collagenous host defense lectins, designated collectins. There is increasing evidence that SP-D, like SP-A, is an important component of the innate immune response to microbial challenge, and that it may participate in other aspects of immune and inflammatory regulation within the lung. SP-D binds to glycoconjugates and/or lipid moieties expressed by a wide variety of microorganisms and certain other organic particles, in vitro. Although binding may facilitate microbial clearance through aggregation or other direct effects on the organism, SP-D also has the capacity to modulate leukocyte function, and in some circumstances, to enhance their killing of microorganisms. Copyright (C) 1998 Elsevier Science B.V.
AB - Surfactant protein D (SP-D) is a member of the family of collagenous host defense lectins, designated collectins. There is increasing evidence that SP-D, like SP-A, is an important component of the innate immune response to microbial challenge, and that it may participate in other aspects of immune and inflammatory regulation within the lung. SP-D binds to glycoconjugates and/or lipid moieties expressed by a wide variety of microorganisms and certain other organic particles, in vitro. Although binding may facilitate microbial clearance through aggregation or other direct effects on the organism, SP-D also has the capacity to modulate leukocyte function, and in some circumstances, to enhance their killing of microorganisms. Copyright (C) 1998 Elsevier Science B.V.
UR - http://www.scopus.com/inward/record.url?scp=0031795751&partnerID=8YFLogxK
U2 - 10.1016/S0925-4439(98)00073-8
DO - 10.1016/S0925-4439(98)00073-8
M3 - Review article
C2 - 9813367
AN - SCOPUS:0031795751
SN - 0925-4439
VL - 1408
SP - 278
EP - 289
JO - Biochimica et Biophysica Acta - Molecular Basis of Disease
JF - Biochimica et Biophysica Acta - Molecular Basis of Disease
IS - 2-3
ER -