Structure, biologic properties, and expression of surfactant protein D (SP-D)

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Abstract

Surfactant protein D (SP-D) is a member of the family of collagenous host defense lectins, designated collectins. There is increasing evidence that SP-D, like SP-A, is an important component of the innate immune response to microbial challenge, and that it may participate in other aspects of immune and inflammatory regulation within the lung. SP-D binds to glycoconjugates and/or lipid moieties expressed by a wide variety of microorganisms and certain other organic particles, in vitro. Although binding may facilitate microbial clearance through aggregation or other direct effects on the organism, SP-D also has the capacity to modulate leukocyte function, and in some circumstances, to enhance their killing of microorganisms. Copyright (C) 1998 Elsevier Science B.V.

Original languageEnglish
Pages (from-to)278-289
Number of pages12
JournalBiochimica et Biophysica Acta - Molecular Basis of Disease
Volume1408
Issue number2-3
DOIs
StatePublished - Nov 19 1998

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