Structure-based discovery of small molecule hepsin and HGFA protease inhibitors: Evaluation of potency and selectivity derived from distinct binding pockets

Keyphrases

• Small Molecules 100%
• Hepatocyte Growth Factor 100%
• Protease Inhibitors 100%
• Hepsin 100%
• Binding Pocket 100%
• Inhibitor Evaluation 100%
• Matriptase 60%
• Protease 30%
• Active Sites 20%
• Benzamidine 20%
• Phenylalanine 10%
• Urea 10%
• Tyrosine Kinase 10%
• Structure-activity Relationship 10%
• Small Molecule Inhibitors 10%
• Chromogenic Substrate 10%
• Enzyme Activity 10%
• Arginine 10%
• Nonapeptides 10%
• Cell Signaling Pathways 10%
• Trypsin-like 10%
• Piperazinyl 10%
• Peptidomimetics 10%
• Pathways in Cancer 10%
• Fluorogenic Substrate 10%
• Serine Endopeptidases 10%
• C-Met 10%
• Irreversible Inhibitor 10%
• Cancer Pathways 10%
• Docking Model 10%
• Compound Library 10%
• Nafamostat 10%
• Enzyme Assay 10%
• Transmembrane Protease 10%
• Nonpeptide Inhibitors 10%
• Inhibitor Scaffold 10%

Biochemistry, Genetics and Molecular Biology

• Small Molecule 100%
• Hepatocyte Growth Factor 100%
• Protease Inhibitor 100%
• Hepsin 100%
• Matriptase 60%
• Protease 40%
• Active Site 20%
• Signal Transduction 20%
• Receptor Tyrosine Kinase 10%
• Tyrosine Kinase 10%
• Structure Activity Relation 10%
• Enzyme Activity 10%
• Serine Protease 10%
• Peptidomimetic 10%
• Enzyme Assay 10%
• Blood Plasma 10%
• Arginine 10%
• Phenylalanine 10%

Pharmacology, Toxicology and Pharmaceutical Science

• Scatter Factor 100%
• Proteinase Inhibitor 100%
• Hepsin 100%
• Matriptase 60%
• Proteinase 40%
• Malignant Neoplasm 20%
• Benzamidine 20%
• Protein Tyrosine Kinase 10%
• Structure Activity Relationship 10%
• Arginine 10%
• Phenylalanine 10%
• Serine Proteinase 10%
• Enzyme Kinetics 10%
• Chromogenic Substrate 10%
• Nafamstat 10%
• Peptidomimetics 10%