Structure based design and synthesis of peptide inhibitor of human lox-12: In vitro and in vivo analysis of a novel therapeutic agent for breast cancer

Agriculture & Biology

• breast neoplasms 100%
• therapeutics 67%
• peptides 59%
• synthesis 47%
• neoplasm cells 34%
• prostaglandin synthase 27%
• lipoxygenases 26%
• growth factors 23%
• estrogens 22%
• prostaglandins 22%
• neoplasms 19%
• surface plasmon resonance 17%
• kinetics 16%
• peptide hormones 15%
• enzyme inhibition 14%
• epidermal growth factor 14%
• in vivo studies 13%
• steroid hormones 13%
• arachidonic acid 12%
• cell viability 11%
• apoptosis 11%
• cell proliferation 11%
• inhibitory concentration 50 10%
• complement 10%
• phospholipids 10%
• cell lines 9%
• hydrolysis 9%
• fatty acids 8%
• receptors 8%
• mice 7%
• assays 6%
• enzymes 5%

Medicine & Life Sciences

• Breast Neoplasms 55%
• Peptides 55%
• In Vitro Techniques 38%
• Lipoxygenase 37%
• Prostaglandin-Endoperoxide Synthases 31%
• Prostaglandins 27%
• Estrogens 23%
• Intercellular Signaling Peptides and Proteins 23%
• Solid-Phase Synthesis Techniques 23%
• baicalein 21%
• Kinetics 21%
• Surface Plasmon Resonance 18%
• Peptide Hormones 17%
• Enzymes 15%
• MCF-7 Cells 15%
• Arachidonic Acid 14%
• Therapeutics 14%
• Epidermal Growth Factor 14%
• Hydrolysis 13%
• Lead 13%
• Phospholipids 13%
• Fatty Acids 12%
• Cell Survival 11%
• Steroids 10%
• Chronic Disease 10%
• Hormones 10%
• Cell Proliferation 9%
• Neoplasms 9%
• Apoptosis 8%
• Cell Line 8%
• Growth 7%

Chemical Compounds

• Peptide 50%
• Growth Factor 34%
• Prostaglandin 33%
• Estrogen 31%
• Baicalein 21%
• Peptide Hormone 19%
• Steroid Hormone 18%
• Enzyme Inhibition 17%
• Haemolytic 16%
• Arachidonic Acid 16%
• Cell Viability 14%
• Surface Plasmon Resonance 13%
• Dissociation Constant 13%
• Phospholipid 12%
• Fatty Acid 11%
• Hydrolysis 8%