Structure and medium effects on hydraphile synthetic ion channel toxicity to the bacterium E. coli

W. Matthew Leevy, Michael R. Gokel, George B. Hughes-Strange, Paul H. Schlesinger, George W. Gokel

Research output: Contribution to journalArticlepeer-review

20 Scopus citations

Abstract

Synthetic hydraphile channels were systematically varied at the side arm position and tested under neutral and acidic conditions against the Gram-negative bacterium E. coli. Side arm structure is a critical determinant of channel activity within the bilayer and greatly influences toxicity. The biological activity data correlate remarkably well with the results of Na + transport studies conducted using synthetic liposome systems. Experiments to determine minimum inhibitory concentrations (MIC) were conducted under both neutral and acidic conditions. Hydraphile toxicity was diminished at pH = 5.5, compared to that at pH = ∼7, providing an example of a pH-dependent, synthetic, non-peptide ion channel.

Original languageEnglish
Pages (from-to)205-209
Number of pages5
JournalNew Journal of Chemistry
Volume29
Issue number1
DOIs
StatePublished - Jan 2005

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