TY - JOUR
T1 - Structure and medium effects on hydraphile synthetic ion channel toxicity to the bacterium E. coli
AU - Leevy, W. Matthew
AU - Gokel, Michael R.
AU - Hughes-Strange, George B.
AU - Schlesinger, Paul H.
AU - Gokel, George W.
PY - 2005/1
Y1 - 2005/1
N2 - Synthetic hydraphile channels were systematically varied at the side arm position and tested under neutral and acidic conditions against the Gram-negative bacterium E. coli. Side arm structure is a critical determinant of channel activity within the bilayer and greatly influences toxicity. The biological activity data correlate remarkably well with the results of Na + transport studies conducted using synthetic liposome systems. Experiments to determine minimum inhibitory concentrations (MIC) were conducted under both neutral and acidic conditions. Hydraphile toxicity was diminished at pH = 5.5, compared to that at pH = ∼7, providing an example of a pH-dependent, synthetic, non-peptide ion channel.
AB - Synthetic hydraphile channels were systematically varied at the side arm position and tested under neutral and acidic conditions against the Gram-negative bacterium E. coli. Side arm structure is a critical determinant of channel activity within the bilayer and greatly influences toxicity. The biological activity data correlate remarkably well with the results of Na + transport studies conducted using synthetic liposome systems. Experiments to determine minimum inhibitory concentrations (MIC) were conducted under both neutral and acidic conditions. Hydraphile toxicity was diminished at pH = 5.5, compared to that at pH = ∼7, providing an example of a pH-dependent, synthetic, non-peptide ion channel.
UR - http://www.scopus.com/inward/record.url?scp=13244267165&partnerID=8YFLogxK
U2 - 10.1039/b413048k
DO - 10.1039/b413048k
M3 - Article
AN - SCOPUS:13244267165
SN - 1144-0546
VL - 29
SP - 205
EP - 209
JO - New Journal of Chemistry
JF - New Journal of Chemistry
IS - 1
ER -