Structure and function of 3α-hydroxysteroid dehydrogenase

Keyphrases

• Hydroxysteroid Dehydrogenase 100%
• Apolar 83%
• Steroid Hormones 66%
• Nicotinamide 50%
• Catalytic Tetrad 50%
• Rat Liver 33%
• Testosterone 33%
• Aldo-keto Reductase 33%
• Flexible Loop 33%
• Aldo-keto Reductase Superfamily 33%
• Short-chain Dehydrogenase/reductase 33%
• Binding Site 16%
• NADP+ 16%
• Protein Folding 16%
• Water Molecule 16%
• Active Sites 16%
• Mutagenesis Studies 16%
• NAD(P) 16%
• Protein Family 16%
• Occupancy 16%
• Common Mechanisms 16%
• Site-directed mutagenesis 16%
• Molecular Cloning 16%
• Sequence Identity 16%
• Steroid Binding 16%
• Carbonyl 16%
• Complex Structure 16%
• Apoenzyme 16%
• X-ray Crystal Structure 16%
• Close Proximity 16%
• Extended Conformation 16%
• Ternary Complex 16%
• Steroid Receptors 16%
• Catalytic Mechanism 16%
• Rational Basis 16%
• Convergent Evolution 16%
• Bond Distance 16%
• General Acid 16%
• A-face 16%
• Structure-based Inhibitor Design 16%
• Positionally 16%
• Structural Template 16%
• Nicotinamide Adenine Dinucleotide Phosphate (NADPH) 16%
• Hydrogen Bond (H-bond) 16%
• 3-ketosteroids 16%
• Hormone Recognition 16%
• Oxidoreduction 16%

Biochemistry, Genetics and Molecular Biology

• Hydroxysteroid Dehydrogenase 100%
• Steroids 100%
• Aldo-Keto Reductase 66%
• Nicotinamide 50%
• Oxidoreductase 33%
• Reductase 33%
• Steroid Binding 33%
• Flexible Loop 33%
• Short-Chain Dehydrogenase 33%
• Testosterone 33%
• Rat 33%
• Binding Site 16%
• Active Site 16%
• Nicotinamide Adenine Dinucleotide Phosphate 16%
• Crystal Structure 16%
• Mutagenesis 16%
• DNA Template 16%
• Conformation 16%
• Hydrogen Bond 16%
• X Ray 16%
• Protein Family 16%
• Target Tissue 16%
• Site-Directed Mutagenesis 16%
• Adenine 16%
• Molecular Cloning 16%
• Hormone Receptor 16%
• Ternary Complex 16%
• Catalytic Mechanism 16%
• Oxidation Reduction Reaction 16%
• Convergent Evolution 16%
• Protein Tertiary Structure 16%