Structure and chromosomal localization of mouse G protein subunit γ4 gene

S. Kalyanaraman, N. G. Copeland, D. G. Gilbert, N. A. Jenkins, N. Gautam

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13 Scopus citations

Abstract

The G protein γ subunits are members of a multigene family and are implicated in determining the specificity of receptor-G protein interaction. The gene structures for many of the γ subunits remain to be determined. Here, we report the gene structure for the brain-specific γ4 subunit and its map position on a mouse chromosome. The gene (Gng4) comprises at least three exons spanning over 20 kb. The 225-bp coding region, which spans two exons, is interrupted by a large 18.2-kb intron whose position is conserved in other γ subunit genes. There is a putative additional intron in the 5' untranslated region just upstream of the translation initiation codon. Introns are present in most of the other γ subunits at this position. The mouse Gng4 gene is mapped to chromosome 13.

Original languageEnglish
Pages (from-to)147-151
Number of pages5
JournalGenomics
Volume49
Issue number1
DOIs
StatePublished - Apr 1 1998

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    Kalyanaraman, S., Copeland, N. G., Gilbert, D. G., Jenkins, N. A., & Gautam, N. (1998). Structure and chromosomal localization of mouse G protein subunit γ4 gene. Genomics, 49(1), 147-151. https://doi.org/10.1006/geno.1998.5223