Structure-activity studies of fluoroalkyl-substituted γ-butyrolactone and γ-thiobutyrolactone modulators of GABA(A) receptor function

Keyphrases

• Receptor Function 100%
• GABAA Receptor (GABAAR) 100%
• Ethyl 100%
• γ-butyrolactone 100%
• Picrotoxin 100%
• Structure-activity Studies 100%
• Fluoroalkyl 100%
• Convulsant Activity 100%
• Methyl 75%
• Fluorination 75%
• 3(2H)-furanones 75%
• Anticonvulsant 50%
• Trifluoromethyl 50%
• C(V) 50%
• Trifluoromethyl Group 50%
• Binding Site 25%
• Non-competitive 25%
• Alkyl 25%
• In(III) 25%
• Cultured Hippocampal Neurons 25%
• Brain Concentration 25%
• Stereochemical Hypothesis 25%
• Binding Interaction 25%
• Electrophysiological Techniques 25%
• Pharmacological Activities 25%
• Sulfur 25%
• Tert 25%
• Heteroatom Substitution 25%
• Oxygen Heteroatom 25%
• Alkyl Group 25%
• Methylene 25%
• 1-Methyl 25%
• Anticonvulsant Action 25%
• Heterocyclic Rings 25%
• Trifluoroethylene 25%
• Steric Constraint 25%
• Fluoroalkyl Groups 25%
• Thiophenone 25%

Pharmacology, Toxicology and Pharmaceutical Science

• Receptor 100%
• 4 Aminobutyric Acid 100%
• Picrotoxin 100%
• Butyrolactone 100%
• Anticonvulsive Agent 50%
• Binding Site 25%
• Tert Butylbicyclophosphorothioate 25%
• Sulfur 35 25%
• Pharmacological Activity 25%
• Sulfur 25%
• Alkyl Group 25%
• Gamma-Butyrolactone 25%
• Carbene 25%