Structure activity relationships of non-peptide bradykinin B2 receptor antagonists

Joseph M. Salvino; Peter R. Seoane; Brent D. Douty; Mohamed A. Awad; Denton Hoyer; Tina Morgan Ross; Roland E. Dolle; Wayne T. Houck; David M. Faunce; David G. Sawutz

doi:10.1016/0960-894X(95)00035-R

Structure activity relationships of non-peptide bradykinin B₂ receptor antagonists

Joseph M. Salvino
, Peter R. Seoane
, Brent D. Douty
, Mohamed A. Awad
, Denton Hoyer
, Tina Morgan Ross
, Roland E. Dolle
, Wayne T. Houck
, David M. Faunce
, David G. Sawutz

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

A series of non-peptide competitive antagonists of the human IMR 90 fetal lung fibroblast bradykinin B₂ receptor have been designed and synthesized. Compound 15 binds with an affinity constant K_i = 60 nM. The SAR leading to the design of these non-peptide antagonists is described.

Original language	English
Pages (from-to)	357-362
Number of pages	6
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	5
Issue number	4
DOIs	https://doi.org/10.1016/0960-894X(95)00035-R
State	Published - Feb 16 1995

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title = "Structure activity relationships of non-peptide bradykinin B2 receptor antagonists",

abstract = "A series of non-peptide competitive antagonists of the human IMR 90 fetal lung fibroblast bradykinin B2 receptor have been designed and synthesized. Compound 15 binds with an affinity constant Ki = 60 nM. The SAR leading to the design of these non-peptide antagonists is described.",

author = "Salvino, \{Joseph M.\} and Seoane, \{Peter R.\} and Douty, \{Brent D.\} and Awad, \{Mohamed A.\} and Denton Hoyer and Ross, \{Tina Morgan\} and Dolle, \{Roland E.\} and Houck, \{Wayne T.\} and Faunce, \{David M.\} and Sawutz, \{David G.\}",

year = "1995",

month = feb,

day = "16",

doi = "10.1016/0960-894X(95)00035-R",

language = "English",

volume = "5",

pages = "357--362",

journal = "Bioorganic and Medicinal Chemistry Letters",

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number = "4",

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TY - JOUR

T1 - Structure activity relationships of non-peptide bradykinin B2 receptor antagonists

AU - Salvino, Joseph M.

AU - Seoane, Peter R.

AU - Douty, Brent D.

AU - Awad, Mohamed A.

AU - Hoyer, Denton

AU - Ross, Tina Morgan

AU - Dolle, Roland E.

AU - Houck, Wayne T.

AU - Faunce, David M.

AU - Sawutz, David G.

PY - 1995/2/16

Y1 - 1995/2/16

N2 - A series of non-peptide competitive antagonists of the human IMR 90 fetal lung fibroblast bradykinin B2 receptor have been designed and synthesized. Compound 15 binds with an affinity constant Ki = 60 nM. The SAR leading to the design of these non-peptide antagonists is described.

AB - A series of non-peptide competitive antagonists of the human IMR 90 fetal lung fibroblast bradykinin B2 receptor have been designed and synthesized. Compound 15 binds with an affinity constant Ki = 60 nM. The SAR leading to the design of these non-peptide antagonists is described.

UR - https://www.scopus.com/pages/publications/0028890972

U2 - 10.1016/0960-894X(95)00035-R

DO - 10.1016/0960-894X(95)00035-R

M3 - Article

AN - SCOPUS:0028890972

SN - 0960-894X

VL - 5

SP - 357

EP - 362

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 4

ER -

Structure activity relationships of non-peptide bradykinin B₂ receptor antagonists

Abstract

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