Structure activity relationships of non-peptide bradykinin B2 receptor antagonists

Joseph M. Salvino; Peter R. Seoane; Brent D. Douty; Mohamed A. Awad; Denton Hoyer; Tina Morgan Ross; Roland E. Dolle; Wayne T. Houck; David M. Faunce; David G. Sawutz

doi:10.1016/0960-894X(95)00035-R

Structure activity relationships of non-peptide bradykinin B₂ receptor antagonists

Joseph M. Salvino, Peter R. Seoane, Brent D. Douty, Mohamed A. Awad, Denton Hoyer, Tina Morgan Ross, Roland E. Dolle, Wayne T. Houck, David M. Faunce, David G. Sawutz

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

A series of non-peptide competitive antagonists of the human IMR 90 fetal lung fibroblast bradykinin B₂ receptor have been designed and synthesized. Compound 15 binds with an affinity constant K_i = 60 nM. The SAR leading to the design of these non-peptide antagonists is described.

Original language	English
Pages (from-to)	357-362
Number of pages	6
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	5
Issue number	4
DOIs	https://doi.org/10.1016/0960-894X(95)00035-R
State	Published - Feb 16 1995

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title = "Structure activity relationships of non-peptide bradykinin B2 receptor antagonists",

abstract = "A series of non-peptide competitive antagonists of the human IMR 90 fetal lung fibroblast bradykinin B2 receptor have been designed and synthesized. Compound 15 binds with an affinity constant Ki = 60 nM. The SAR leading to the design of these non-peptide antagonists is described.",

author = "Salvino, {Joseph M.} and Seoane, {Peter R.} and Douty, {Brent D.} and Awad, {Mohamed A.} and Denton Hoyer and Ross, {Tina Morgan} and Dolle, {Roland E.} and Houck, {Wayne T.} and Faunce, {David M.} and Sawutz, {David G.}",

year = "1995",

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doi = "10.1016/0960-894X(95)00035-R",

language = "English",

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pages = "357--362",

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T1 - Structure activity relationships of non-peptide bradykinin B2 receptor antagonists

AU - Salvino, Joseph M.

AU - Seoane, Peter R.

AU - Douty, Brent D.

AU - Awad, Mohamed A.

AU - Hoyer, Denton

AU - Ross, Tina Morgan

AU - Dolle, Roland E.

AU - Houck, Wayne T.

AU - Faunce, David M.

AU - Sawutz, David G.

PY - 1995/2/16

Y1 - 1995/2/16

N2 - A series of non-peptide competitive antagonists of the human IMR 90 fetal lung fibroblast bradykinin B2 receptor have been designed and synthesized. Compound 15 binds with an affinity constant Ki = 60 nM. The SAR leading to the design of these non-peptide antagonists is described.

AB - A series of non-peptide competitive antagonists of the human IMR 90 fetal lung fibroblast bradykinin B2 receptor have been designed and synthesized. Compound 15 binds with an affinity constant Ki = 60 nM. The SAR leading to the design of these non-peptide antagonists is described.

UR - http://www.scopus.com/inward/record.url?scp=0028890972&partnerID=8YFLogxK

U2 - 10.1016/0960-894X(95)00035-R

DO - 10.1016/0960-894X(95)00035-R

M3 - Article

AN - SCOPUS:0028890972

SN - 0960-894X

VL - 5

SP - 357

EP - 362

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 4

ER -

Structure activity relationships of non-peptide bradykinin B₂ receptor antagonists

Abstract

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