Structure activity relationships of non-peptide bradykinin B2 receptor antagonists

Joseph M. Salvino, Peter R. Seoane, Brent D. Douty, Mohamed A. Awad, Denton Hoyer, Tina Morgan Ross, Roland E. Dolle, Wayne T. Houck, David M. Faunce, David G. Sawutz

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

A series of non-peptide competitive antagonists of the human IMR 90 fetal lung fibroblast bradykinin B2 receptor have been designed and synthesized. Compound 15 binds with an affinity constant Ki = 60 nM. The SAR leading to the design of these non-peptide antagonists is described.

Original languageEnglish
Pages (from-to)357-362
Number of pages6
JournalBioorganic and Medicinal Chemistry Letters
Volume5
Issue number4
DOIs
StatePublished - Feb 16 1995
Externally publishedYes

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    Salvino, J. M., Seoane, P. R., Douty, B. D., Awad, M. A., Hoyer, D., Ross, T. M., Dolle, R. E., Houck, W. T., Faunce, D. M., & Sawutz, D. G. (1995). Structure activity relationships of non-peptide bradykinin B2 receptor antagonists. Bioorganic and Medicinal Chemistry Letters, 5(4), 357-362. https://doi.org/10.1016/0960-894X(95)00035-R