Structure activity relations of antagonists of the renin angiotensin system

Research output: Contribution to journalReview articlepeer-review

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Abstract

In this review, inhibitors of the renin angiotensin system, both naturally occurring and synthetic, are considered. Inhibition of renin itself, of converting enzyme (dipeptidyl carboxypeptidase), and of interaction with the receptor is characterized from the point of view of mechanism, structure activity relations, and future developments. The concept of transition state analog and its relevance to the inhibition of renin by pepstatin is discussed. Questions concerning selectivity, increased affinity, and longer duration of action are raised with regard to future design of inhibitors of the renin angiotensin system.

Original languageEnglish
Pages (from-to)2494-2501
Number of pages8
JournalFederation proceedings
Volume35
Issue number13
StatePublished - Dec 1 1976

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