Structural Insights into the Mechanisms of Antibody-Mediated Neutralization of Flavivirus Infection: Implications for Vaccine Development

Theodore C. Pierson; Daved H. Fremont; Richard J. Kuhn; Michael S. Diamond

doi:10.1016/j.chom.2008.08.004

Structural Insights into the Mechanisms of Antibody-Mediated Neutralization of Flavivirus Infection: Implications for Vaccine Development

Theodore C. Pierson, Daved H. Fremont, Richard J. Kuhn, Michael S. Diamond

Research output: Contribution to journal › Review article › peer-review

230 Scopus citations

Abstract

Flaviviruses are a group of small RNA viruses that cause severe disease in humans worldwide and are the target of several vaccine development programs. A primary goal of these efforts is to elicit a protective humoral response directed against the envelope proteins arrayed on the surface of the flavivirus virion. Advances in the structural biology of these viruses has catalyzed rapid progress toward understanding the complexity of the flavivirus immunogen and the molecular basis of antibody-mediated neutralization. These insights have identified factors that govern the potency of neutralizing antibodies and will inform the design and evaluation of novel vaccines.

Original language	English
Pages (from-to)	229-238
Number of pages	10
Journal	Cell Host and Microbe
Volume	4
Issue number	3
DOIs	https://doi.org/10.1016/j.chom.2008.08.004
State	Published - Sep 11 2008

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10.1016/j.chom.2008.08.004

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title = "Structural Insights into the Mechanisms of Antibody-Mediated Neutralization of Flavivirus Infection: Implications for Vaccine Development",

abstract = "Flaviviruses are a group of small RNA viruses that cause severe disease in humans worldwide and are the target of several vaccine development programs. A primary goal of these efforts is to elicit a protective humoral response directed against the envelope proteins arrayed on the surface of the flavivirus virion. Advances in the structural biology of these viruses has catalyzed rapid progress toward understanding the complexity of the flavivirus immunogen and the molecular basis of antibody-mediated neutralization. These insights have identified factors that govern the potency of neutralizing antibodies and will inform the design and evaluation of novel vaccines.",

author = "Pierson, {Theodore C.} and Fremont, {Daved H.} and Kuhn, {Richard J.} and Diamond, {Michael S.}",

note = "Funding Information: This work was supported by the intramural program of the National Institute of Allergy and Infectious Diseases (NIAID) (T.C.P.), the Pediatric Dengue Vaccine Initiative (PDVI) (individual awards to T.C.P., D.H.F., R.J.K., and M.S.D.), NIH grants AI55672 (R.J.K.), AI061373, AI073755, and AI77955 (M.S.D.), and a Burroughs Wellcome Fund Clinical Scientist Award (M.S.D.).",

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AU - Kuhn, Richard J.

AU - Diamond, Michael S.

N1 - Funding Information: This work was supported by the intramural program of the National Institute of Allergy and Infectious Diseases (NIAID) (T.C.P.), the Pediatric Dengue Vaccine Initiative (PDVI) (individual awards to T.C.P., D.H.F., R.J.K., and M.S.D.), NIH grants AI55672 (R.J.K.), AI061373, AI073755, and AI77955 (M.S.D.), and a Burroughs Wellcome Fund Clinical Scientist Award (M.S.D.).

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N2 - Flaviviruses are a group of small RNA viruses that cause severe disease in humans worldwide and are the target of several vaccine development programs. A primary goal of these efforts is to elicit a protective humoral response directed against the envelope proteins arrayed on the surface of the flavivirus virion. Advances in the structural biology of these viruses has catalyzed rapid progress toward understanding the complexity of the flavivirus immunogen and the molecular basis of antibody-mediated neutralization. These insights have identified factors that govern the potency of neutralizing antibodies and will inform the design and evaluation of novel vaccines.

AB - Flaviviruses are a group of small RNA viruses that cause severe disease in humans worldwide and are the target of several vaccine development programs. A primary goal of these efforts is to elicit a protective humoral response directed against the envelope proteins arrayed on the surface of the flavivirus virion. Advances in the structural biology of these viruses has catalyzed rapid progress toward understanding the complexity of the flavivirus immunogen and the molecular basis of antibody-mediated neutralization. These insights have identified factors that govern the potency of neutralizing antibodies and will inform the design and evaluation of novel vaccines.

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DO - 10.1016/j.chom.2008.08.004

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Structural Insights into the Mechanisms of Antibody-Mediated Neutralization of Flavivirus Infection: Implications for Vaccine Development

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