Structural and stereochemical requirements of time-dependent inactivators of the interleukin-1β converting enzyme

C. V.C. Prasad, Catherine P. Prouty, Denton Hoyer, Tina M. Ross, Joseph M. Salvino, Mohamad Awad, Todd L. Graybill, Stanley J. Schmidt, I. Kelly Osifo, Roland E. Dolle, Carla T. Helaszek, Robert E. Miller, Mark A. Ator

Research output: Contribution to journalArticle

24 Scopus citations

Abstract

Structural and stereochemical requirements of substrate based time-dependent inactivators of interleukin-1β converting enzyme were investigated. Hydrophobic amino acids with L-stereochemistry are preferred at the P2 and P3 positions. It appears that both D-and L-Asp are accepted by the enzyme at the PI position.

Original languageEnglish
Pages (from-to)315-318
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume5
Issue number4
DOIs
StatePublished - Feb 16 1995
Externally publishedYes

Fingerprint Dive into the research topics of 'Structural and stereochemical requirements of time-dependent inactivators of the interleukin-1β converting enzyme'. Together they form a unique fingerprint.

  • Cite this

    Prasad, C. V. C., Prouty, C. P., Hoyer, D., Ross, T. M., Salvino, J. M., Awad, M., Graybill, T. L., Schmidt, S. J., Kelly Osifo, I., Dolle, R. E., Helaszek, C. T., Miller, R. E., & Ator, M. A. (1995). Structural and stereochemical requirements of time-dependent inactivators of the interleukin-1β converting enzyme. Bioorganic and Medicinal Chemistry Letters, 5(4), 315-318. https://doi.org/10.1016/0960-894X(95)00027-Q