Structural and stereochemical requirements of time-dependent inactivators of the interleukin-1β converting enzyme

C. V.C. Prasad; Catherine P. Prouty; Denton Hoyer; Tina M. Ross; Joseph M. Salvino; Mohamad Awad; Todd L. Graybill; Stanley J. Schmidt; I. Kelly Osifo; Roland E. Dolle; Carla T. Helaszek; Robert E. Miller; Mark A. Ator

doi:10.1016/0960-894X(95)00027-Q

Structural and stereochemical requirements of time-dependent inactivators of the interleukin-1β converting enzyme

C. V.C. Prasad, Catherine P. Prouty, Denton Hoyer, Tina M. Ross, Joseph M. Salvino, Mohamad Awad, Todd L. Graybill, Stanley J. Schmidt, I. Kelly Osifo, Roland E. Dolle, Carla T. Helaszek, Robert E. Miller, Mark A. Ator

Center for Drug Discovery

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Abstract

Structural and stereochemical requirements of substrate based time-dependent inactivators of interleukin-1β converting enzyme were investigated. Hydrophobic amino acids with L-stereochemistry are preferred at the P₂ and P₃ positions. It appears that both D-and L-Asp are accepted by the enzyme at the P_I position.

Original language	English
Pages (from-to)	315-318
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	5
Issue number	4
DOIs	https://doi.org/10.1016/0960-894X(95)00027-Q
State	Published - Feb 16 1995

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Prasad, C. V. C., Prouty, C. P., Hoyer, D., Ross, T. M., Salvino, J. M., Awad, M., Graybill, T. L., Schmidt, S. J., Kelly Osifo, I., Dolle, R. E., Helaszek, C. T., Miller, R. E., & Ator, M. A. (1995). Structural and stereochemical requirements of time-dependent inactivators of the interleukin-1β converting enzyme. Bioorganic and Medicinal Chemistry Letters, 5(4), 315-318. https://doi.org/10.1016/0960-894X(95)00027-Q

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abstract = "Structural and stereochemical requirements of substrate based time-dependent inactivators of interleukin-1β converting enzyme were investigated. Hydrophobic amino acids with L-stereochemistry are preferred at the P2 and P3 positions. It appears that both D-and L-Asp are accepted by the enzyme at the PI position.",

author = "Prasad, {C. V.C.} and Prouty, {Catherine P.} and Denton Hoyer and Ross, {Tina M.} and Salvino, {Joseph M.} and Mohamad Awad and Graybill, {Todd L.} and Schmidt, {Stanley J.} and {Kelly Osifo}, I. and Dolle, {Roland E.} and Helaszek, {Carla T.} and Miller, {Robert E.} and Ator, {Mark A.}",

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doi = "10.1016/0960-894X(95)00027-Q",

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Prasad, CVC, Prouty, CP, Hoyer, D, Ross, TM, Salvino, JM, Awad, M, Graybill, TL, Schmidt, SJ, Kelly Osifo, I, Dolle, RE, Helaszek, CT, Miller, RE & Ator, MA 1995, 'Structural and stereochemical requirements of time-dependent inactivators of the interleukin-1β converting enzyme', Bioorganic and Medicinal Chemistry Letters, vol. 5, no. 4, pp. 315-318. https://doi.org/10.1016/0960-894X(95)00027-Q

TY - JOUR

T1 - Structural and stereochemical requirements of time-dependent inactivators of the interleukin-1β converting enzyme

AU - Prasad, C. V.C.

AU - Prouty, Catherine P.

AU - Hoyer, Denton

AU - Ross, Tina M.

AU - Salvino, Joseph M.

AU - Awad, Mohamad

AU - Graybill, Todd L.

AU - Schmidt, Stanley J.

AU - Kelly Osifo, I.

AU - Dolle, Roland E.

AU - Helaszek, Carla T.

AU - Miller, Robert E.

AU - Ator, Mark A.

PY - 1995/2/16

Y1 - 1995/2/16

N2 - Structural and stereochemical requirements of substrate based time-dependent inactivators of interleukin-1β converting enzyme were investigated. Hydrophobic amino acids with L-stereochemistry are preferred at the P2 and P3 positions. It appears that both D-and L-Asp are accepted by the enzyme at the PI position.

AB - Structural and stereochemical requirements of substrate based time-dependent inactivators of interleukin-1β converting enzyme were investigated. Hydrophobic amino acids with L-stereochemistry are preferred at the P2 and P3 positions. It appears that both D-and L-Asp are accepted by the enzyme at the PI position.

UR - http://www.scopus.com/inward/record.url?scp=0028830796&partnerID=8YFLogxK

U2 - 10.1016/0960-894X(95)00027-Q

DO - 10.1016/0960-894X(95)00027-Q

M3 - Article

AN - SCOPUS:0028830796

SN - 0960-894X

VL - 5

SP - 315

EP - 318

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 4

ER -

Structural and stereochemical requirements of time-dependent inactivators of the interleukin-1β converting enzyme

Abstract

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