Structural and functional roles of ether lipids

John M. Dean, Irfan J. Lodhi

Research output: Contribution to journalReview article

78 Scopus citations

Abstract

Ether lipids, such as plasmalogens, are peroxisome-derived glycerophospholipids in which the hydrocarbon chain at the sn-1 position of the glycerol backbone is attached by an ether bond, as opposed to an ester bond in the more common diacyl phospholipids. This seemingly simple biochemical change has profound structural and functional implications. Notably, the tendency of ether lipids to form non-lamellar inverted hexagonal structures in model membranes suggests that they have a role in facilitating membrane fusion processes. Ether lipids are also important for the organization and stability of lipid raft microdomains, cholesterol-rich membrane regions involved in cellular signaling. In addition to their structural roles, a subset of ether lipids are thought to function as endogenous antioxidants, and emerging studies suggest that they are involved in cell differentiation and signaling pathways. Here, we review the biology of ether lipids and their potential significance in human disorders, including neurological diseases, cancer, and metabolic disorders.

Original languageEnglish
Pages (from-to)196-206
Number of pages11
JournalProtein and Cell
Volume9
Issue number2
DOIs
StatePublished - Feb 1 2018

Keywords

  • cancer
  • ether lipids
  • metabolic disorders
  • peroxisomes
  • phospholipid
  • plasmalogen

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