TY - JOUR
T1 - Structural and functional features on quantitative chest computed tomography in the korean asian versus the white american healthy non-smokers
AU - National Heart, Lung and Blood Institute’s SubPopulations and InteRmediate Outcome Measures In COPD Study (SPIROMICS)
AU - Severe Asthma Research Program (SARP)
AU - Cho, Hyun Bin
AU - Chae, Kum Ju
AU - Jin, Gong Yong
AU - Choi, Jiwoong
AU - Lin, Ching Long
AU - Hoffman, Eric A.
AU - Wenzel, Sally E.
AU - Castro, Mario
AU - Fain, Sean B.
AU - Jarjour, Nizar N.
AU - Schiebler, Mark L.
AU - Barr, R. Graham
AU - Hansel, Nadia
AU - Cooper, Christopher B.
AU - Kleerup, Eric C.
AU - Han, Meilan K.
AU - Woodruff, Prescott G.
AU - Kanner, Richard E.
AU - Bleecker, Eugene R.
AU - Peters, Stephen P.
AU - Moore, Wendy C.
AU - Lee, Chang Hyun
AU - Choi, Sanghun
N1 - Publisher Copyright:
© 2019 The Korean Society of Radiology.
PY - 2019/7
Y1 - 2019/7
N2 - Objective: Considering the different prevalence rates of diseases such as asthma and chronic obstructive pulmonary disease in Asians relative to other races, Koreans may have unique airway structure and lung function. This study aimed to investigate unique features of airway structure and lung function based on quantitative computed tomography (QCT)-imaging metrics in the Korean Asian population (Koreans) as compared with the White American population (Whites). Materials and Methods: QCT data of healthy non-smokers (223 Koreans vs. 70 Whites) were collected, including QCT structural variables of wall thickness (WT) and hydraulic diameter (Dh) and functional variables of air volume, total air volume change in the lung (ΔVair), percent emphysema-like lung (Emph%), and percent functional small airway disease-like lung (fSAD%). Mann Whitney U tests were performed to compare the two groups. Results: As compared with Whites, Koreans had smaller volume at inspiration, ΔVair between inspiration and expiration (p < 0.001), and Emph% at inspiration (p < 0.001). Especially, Korean females had a decrease of ΔVair in the lower lobes (p < 0.001), associated with fSAD% at the lower lobes (p < 0.05). In addition, Koreans had smaller Dh and WT of the trachea (both, p < 0.05), correlated with the forced expiratory volume in 1 second (R = 0.49, 0.39; all p < 0.001) and forced vital capacity (R = 0.55, 0.45; all p < 0.001). Conclusion: Koreans had unique features of airway structure and lung function as compared with Whites, and the difference was clearer in female individuals. Discriminating structural and functional features between Koreans and Whites enables exploration of inter-racial differences of pulmonary disease in terms of severity, distribution, and phenotype.
AB - Objective: Considering the different prevalence rates of diseases such as asthma and chronic obstructive pulmonary disease in Asians relative to other races, Koreans may have unique airway structure and lung function. This study aimed to investigate unique features of airway structure and lung function based on quantitative computed tomography (QCT)-imaging metrics in the Korean Asian population (Koreans) as compared with the White American population (Whites). Materials and Methods: QCT data of healthy non-smokers (223 Koreans vs. 70 Whites) were collected, including QCT structural variables of wall thickness (WT) and hydraulic diameter (Dh) and functional variables of air volume, total air volume change in the lung (ΔVair), percent emphysema-like lung (Emph%), and percent functional small airway disease-like lung (fSAD%). Mann Whitney U tests were performed to compare the two groups. Results: As compared with Whites, Koreans had smaller volume at inspiration, ΔVair between inspiration and expiration (p < 0.001), and Emph% at inspiration (p < 0.001). Especially, Korean females had a decrease of ΔVair in the lower lobes (p < 0.001), associated with fSAD% at the lower lobes (p < 0.05). In addition, Koreans had smaller Dh and WT of the trachea (both, p < 0.05), correlated with the forced expiratory volume in 1 second (R = 0.49, 0.39; all p < 0.001) and forced vital capacity (R = 0.55, 0.45; all p < 0.001). Conclusion: Koreans had unique features of airway structure and lung function as compared with Whites, and the difference was clearer in female individuals. Discriminating structural and functional features between Koreans and Whites enables exploration of inter-racial differences of pulmonary disease in terms of severity, distribution, and phenotype.
KW - Airway wall thickness
KW - Hydraulic luminal diameter
KW - Image registration
KW - Percent emphysema-like lung
KW - Percent functional small airway disease-like lung
UR - http://www.scopus.com/inward/record.url?scp=85069267879&partnerID=8YFLogxK
U2 - 10.3348/kjr.2019.0083
DO - 10.3348/kjr.2019.0083
M3 - Article
C2 - 31270987
AN - SCOPUS:85069267879
SN - 1229-6929
VL - 20
SP - 1236
EP - 1245
JO - Korean Journal of Radiology
JF - Korean Journal of Radiology
IS - 7
ER -