Stromal osteoclast-like giant cells in an adenosquamous carcinoma of the gallbladder

Leonard F. Grosso, Juan G. Gonzalez

Research output: Contribution to journalArticle

20 Scopus citations

Abstract

We report a case of an adenosquamous carcinoma of the gallbladder that extended to the proximal transverse colon. Metastatic tumor was present in regional lymph nodes and the liver. Microscopically, the tumor was composed of malignant epithelial cells that were cytokeratin-, epithelial membrane antigen-, and carcinoembryonic antigen-positive. The adjacent desmoplastic stroma of the primary tumor, as well as the metastasis, contained giant cells that morphologically resembled osteoclasts. Immunohistochemical studies showed that the giant cells were cytokeratin-, epithelial membrane antigen-, and carcinoembryonic antigen-negative but weakly α1-antichymotrypsin-positive. While tumors containing osteoclast-like giant cells have been described in the breast, lung, liver, and thyroid, this is the first report of a tumor with this morphology originating in the gallbladder. The presence of the giant cells adjacent to both the primary and metastatic tumor and not at any other location suggests that the tumor cells are producing a substance that induces the formation of the nontumoral giant cells.

Original languageEnglish
Pages (from-to)703-706
Number of pages4
JournalHuman Pathology
Volume23
Issue number6
DOIs
StatePublished - Jun 1992

Keywords

  • adenosquamous carcinoma
  • gallbladder
  • osteoclast-like giant cells

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