Stroke detection with 3 different PET tracers

Ayca Dundar; Michael S. Bold; Busranur Agac; Ayse Tuba Kendi; Saul N. Friedman

doi:10.1016/j.radcr.2019.09.005

Stroke detection with 3 different PET tracers

Ayca Dundar, Michael S. Bold, Busranur Agac, Ayse Tuba Kendi, Saul N. Friedman

Division of Nuclear Medicine

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

Stroke is a common cause of patient morbidity and mortality, being the fifth leading cause of death in the United States. Positron emission tomography (PET) is a proven tool for oncology patients, and may have utility in patients with stroke. We demonstrate findings of stroke incidentally detected on oncologic PET/CTs using ¹⁸F-FDG, ¹¹C-Choline, and ⁶⁸Ga-DOTATATE radiotracers. Specifically, focal ¹¹C-Choline or ⁶⁸Ga-DOTATATE uptakes localized in areas of MRI confirmed ischemia, and paradoxically increased ¹⁸F-FDG activity was visualized surrounding a region of hemorrhage, in different patients. These cases demonstrate that PET may have utility in evaluating patients with stroke based on flow dynamics, metabolic activity, and receptor expression.

Original language	English
Pages (from-to)	1447-1451
Number of pages	5
Journal	Radiology Case Reports
Volume	14
Issue number	11
DOIs	https://doi.org/10.1016/j.radcr.2019.09.005
State	Published - Nov 2019

Keywords

11C-Choline
18F-FDG
68Ga-DOTATATE
PET
Stroke

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10.1016/j.radcr.2019.09.005

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title = "Stroke detection with 3 different PET tracers",

abstract = "Stroke is a common cause of patient morbidity and mortality, being the fifth leading cause of death in the United States. Positron emission tomography (PET) is a proven tool for oncology patients, and may have utility in patients with stroke. We demonstrate findings of stroke incidentally detected on oncologic PET/CTs using 18F-FDG, 11C-Choline, and 68Ga-DOTATATE radiotracers. Specifically, focal 11C-Choline or 68Ga-DOTATATE uptakes localized in areas of MRI confirmed ischemia, and paradoxically increased 18F-FDG activity was visualized surrounding a region of hemorrhage, in different patients. These cases demonstrate that PET may have utility in evaluating patients with stroke based on flow dynamics, metabolic activity, and receptor expression.",

keywords = "11C-Choline, 18F-FDG, 68Ga-DOTATATE, PET, Stroke",

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AU - Dundar, Ayca

AU - Bold, Michael S.

AU - Agac, Busranur

AU - Kendi, Ayse Tuba

AU - Friedman, Saul N.

PY - 2019/11

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N2 - Stroke is a common cause of patient morbidity and mortality, being the fifth leading cause of death in the United States. Positron emission tomography (PET) is a proven tool for oncology patients, and may have utility in patients with stroke. We demonstrate findings of stroke incidentally detected on oncologic PET/CTs using 18F-FDG, 11C-Choline, and 68Ga-DOTATATE radiotracers. Specifically, focal 11C-Choline or 68Ga-DOTATATE uptakes localized in areas of MRI confirmed ischemia, and paradoxically increased 18F-FDG activity was visualized surrounding a region of hemorrhage, in different patients. These cases demonstrate that PET may have utility in evaluating patients with stroke based on flow dynamics, metabolic activity, and receptor expression.

AB - Stroke is a common cause of patient morbidity and mortality, being the fifth leading cause of death in the United States. Positron emission tomography (PET) is a proven tool for oncology patients, and may have utility in patients with stroke. We demonstrate findings of stroke incidentally detected on oncologic PET/CTs using 18F-FDG, 11C-Choline, and 68Ga-DOTATATE radiotracers. Specifically, focal 11C-Choline or 68Ga-DOTATATE uptakes localized in areas of MRI confirmed ischemia, and paradoxically increased 18F-FDG activity was visualized surrounding a region of hemorrhage, in different patients. These cases demonstrate that PET may have utility in evaluating patients with stroke based on flow dynamics, metabolic activity, and receptor expression.

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Stroke detection with 3 different PET tracers

Abstract

Keywords

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