Striatal H3K27 Acetylation Linked to Glutamatergic Gene Dysregulation in Human Heroin Abusers Holds Promise as Therapeutic Target

Keyphrases

• Therapeutic Target 100%
• Striatal 100%
• Gene Dysregulation 100%
• Glutamatergic 100%
• H3K27 Acetylation 100%
• Heroin Abusers 100%
• Epigenetics 66%
• Histone H3 66%
• Striatum 66%
• Lysine 66%
• Opiates 66%
• Drug Seeking 66%
• Heroin 66%
• Chromatin Accessibility 66%
• Heroin Self-administration 66%
• Hyperacetylation 66%
• Brain Regions 33%
• United States 33%
• In Vitro Model 33%
• Human Brain 33%
• Clinical Intervention 33%
• Transcriptional Profiling 33%
• Transcriptome 33%
• Addiction-like Behavior 33%
• Neurobiology 33%
• Epigenetic Profiling 33%
• Chromatin Remodeling 33%
• Postmortem Brain 33%
• Transcriptional Changes 33%
• Use History 33%
• Toxicology 33%
• Opioid Overdose 33%
• Molecular Insight 33%
• Caucasian Population 33%
• Human Striatum 33%
• Gene Body 33%
• Functional Readouts 33%
• GRIA1 33%
• Bromodomain Inhibitors 33%
• Translational Model 33%
• Cue-induced Drug Seeking 33%
• Heroin Use 33%
• Biochemical Experiment 33%
• Glutamatergic Neurotransmission 33%
• Acetylated Histone H3 33%
• Acetylated Lysine 33%
• Heroin Use Disorder 33%
• Opiate Abuse 33%
• Dynamic Correlation 33%
• Behavioral Insights 33%
• Self-administration Model 33%
• Heroin Users 33%

Neuroscience

• Heroin 100%
• Acetylation 100%
• Striatum 37%
• Lysine 37%
• Histone H3 37%
• Opiate 25%
• Drug Seeking Behavior 25%
• In Vitro 12%
• Behavior (Neuroscience) 12%
• Chromatin Assembly and Disassembly 12%
• Neuroscience 12%
• Neurotransmission 12%
• Transcriptome 12%
• Clinical Intervention 12%
• GRIA1 12%
• Bromodomain 12%
• Opiate Abuse 12%