Stressing Out about Cancer Immunotherapy

Xue Yan He; David Ng; Linda Van Aelst; Mikala Egeblad

doi:10.1016/j.ccell.2019.10.013

Stressing Out about Cancer Immunotherapy

Xue Yan He
, David Ng
, Linda Van Aelst
, Mikala Egeblad

Research output: Contribution to journal › Short survey › peer-review

10 Scopus citations

Abstract

Stress has long been suspected to negatively influence cancer mortality, yet the molecular mechanisms responsible for this effect have only recently been identified. A new study identifies a stress-induced response in dendritic cells—the activation of the glucocorticoid-inducible transcriptional regulator TSC22D3—as a potent, immunosuppressive effect of stress on cancer.

Original language	English
Pages (from-to)	468-470
Number of pages	3
Journal	Cancer Cell
Volume	36
Issue number	5
DOIs	https://doi.org/10.1016/j.ccell.2019.10.013
State	Published - Nov 11 2019

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10.1016/j.ccell.2019.10.013

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@article{09dd3fc953fa41878138239f449f86f4,

title = "Stressing Out about Cancer Immunotherapy",

abstract = "Stress has long been suspected to negatively influence cancer mortality, yet the molecular mechanisms responsible for this effect have only recently been identified. A new study identifies a stress-induced response in dendritic cells—the activation of the glucocorticoid-inducible transcriptional regulator TSC22D3—as a potent, immunosuppressive effect of stress on cancer.",

author = "He, \{Xue Yan\} and David Ng and \{Van Aelst\}, Linda and Mikala Egeblad",

note = "Publisher Copyright: {\textcopyright} 2019 Elsevier Inc.",

year = "2019",

month = nov,

day = "11",

doi = "10.1016/j.ccell.2019.10.013",

language = "English",

volume = "36",

pages = "468--470",

journal = "Cancer Cell",

issn = "1535-6108",

number = "5",

}

TY - JOUR

T1 - Stressing Out about Cancer Immunotherapy

AU - He, Xue Yan

AU - Ng, David

AU - Van Aelst, Linda

AU - Egeblad, Mikala

PY - 2019/11/11

Y1 - 2019/11/11

N2 - Stress has long been suspected to negatively influence cancer mortality, yet the molecular mechanisms responsible for this effect have only recently been identified. A new study identifies a stress-induced response in dendritic cells—the activation of the glucocorticoid-inducible transcriptional regulator TSC22D3—as a potent, immunosuppressive effect of stress on cancer.

AB - Stress has long been suspected to negatively influence cancer mortality, yet the molecular mechanisms responsible for this effect have only recently been identified. A new study identifies a stress-induced response in dendritic cells—the activation of the glucocorticoid-inducible transcriptional regulator TSC22D3—as a potent, immunosuppressive effect of stress on cancer.

UR - https://www.scopus.com/pages/publications/85074425778

U2 - 10.1016/j.ccell.2019.10.013

DO - 10.1016/j.ccell.2019.10.013

M3 - Short survey

C2 - 31715130

AN - SCOPUS:85074425778

SN - 1535-6108

VL - 36

SP - 468

EP - 470

JO - Cancer Cell

JF - Cancer Cell

IS - 5

ER -

Stressing Out about Cancer Immunotherapy

Abstract

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