Stress Can Induce Transcription of Toxin-Antitoxin Systems without Activating Toxin

Michele LeRoux; Peter H. Culviner; Yue J. Liu; Megan L. Littlehale; Michael T. Laub

doi:10.1016/j.molcel.2020.05.028

Stress Can Induce Transcription of Toxin-Antitoxin Systems without Activating Toxin

Michele LeRoux, Peter H. Culviner, Yue J. Liu, Megan L. Littlehale, Michael T. Laub

Research output: Contribution to journal › Article › peer-review

74 Scopus citations

Abstract

The toxin-antitoxin (TA) systems encoded on bacterial chromosomes have long been thought to act as effectors of a cellular stress response system. LeRoux et al. find that, despite strong transcriptional induction following various stress treatments, the toxins of TA systems are not activated under these conditions.

Original language	English
Pages (from-to)	280-292.e8
Journal	Molecular cell
Volume	79
Issue number	2
DOIs	https://doi.org/10.1016/j.molcel.2020.05.028
State	Published - Jul 16 2020

Keywords

Lon
MqsRA
YefM-YoeB
heat shock
protein degradation
pulse-chase assay

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10.1016/j.molcel.2020.05.028

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title = "Stress Can Induce Transcription of Toxin-Antitoxin Systems without Activating Toxin",

abstract = "The toxin-antitoxin (TA) systems encoded on bacterial chromosomes have long been thought to act as effectors of a cellular stress response system. LeRoux et al. find that, despite strong transcriptional induction following various stress treatments, the toxins of TA systems are not activated under these conditions.",

keywords = "Lon, MqsRA, YefM-YoeB, heat shock, protein degradation, pulse-chase assay",

author = "Michele LeRoux and Culviner, {Peter H.} and Liu, {Yue J.} and Littlehale, {Megan L.} and Laub, {Michael T.}",

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AU - Culviner, Peter H.

AU - Liu, Yue J.

AU - Littlehale, Megan L.

AU - Laub, Michael T.

PY - 2020/7/16

Y1 - 2020/7/16

N2 - The toxin-antitoxin (TA) systems encoded on bacterial chromosomes have long been thought to act as effectors of a cellular stress response system. LeRoux et al. find that, despite strong transcriptional induction following various stress treatments, the toxins of TA systems are not activated under these conditions.

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KW - MqsRA

KW - YefM-YoeB

KW - heat shock

KW - protein degradation

KW - pulse-chase assay

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Stress Can Induce Transcription of Toxin-Antitoxin Systems without Activating Toxin

Abstract

Keywords

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