Abstract
The long term effect of single (day 1) and twice (day 1 and 3) injections of intracerebroventricular (ICV) streptozotocin (STZ) at the doses of 1 and 3 mg/kg on the cognitive functions of male Wistar rats was evaluated. Elevated plus maze, passive avoidance, and Morris water maze tests were used to assess the cognitive functions. A significant cognitive deficit was found at the 2nd week onwards, which persisted up to the 14th week with single and twice ICV-STZ (3 mg/kg) injections, whereas no cognitive impairment was found in ICV-STZ (1 mg/kg) treated groups after 8-10 weeks.
| Original language | English |
|---|---|
| Pages (from-to) | 17-21 |
| Number of pages | 5 |
| Journal | Journal of Alzheimer's Disease |
| Volume | 33 |
| Issue number | 1 |
| DOIs | |
| State | Published - 2013 |
Keywords
- Alzheimer's disease
- Morris water maze
- cognitive impairment
- elevated plus maze
- passive avoidance
- streptozotocin
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