TY - JOUR
T1 - Streptozotocin-induced sporadic Alzheimer's Disease
T2 - Selection of appropriate dose
AU - Mehla, Jogender
AU - Pahuja, Monika
AU - Gupta, Yogendra Kumar
PY - 2013
Y1 - 2013
N2 - The long term effect of single (day 1) and twice (day 1 and 3) injections of intracerebroventricular (ICV) streptozotocin (STZ) at the doses of 1 and 3 mg/kg on the cognitive functions of male Wistar rats was evaluated. Elevated plus maze, passive avoidance, and Morris water maze tests were used to assess the cognitive functions. A significant cognitive deficit was found at the 2nd week onwards, which persisted up to the 14th week with single and twice ICV-STZ (3 mg/kg) injections, whereas no cognitive impairment was found in ICV-STZ (1 mg/kg) treated groups after 8-10 weeks.
AB - The long term effect of single (day 1) and twice (day 1 and 3) injections of intracerebroventricular (ICV) streptozotocin (STZ) at the doses of 1 and 3 mg/kg on the cognitive functions of male Wistar rats was evaluated. Elevated plus maze, passive avoidance, and Morris water maze tests were used to assess the cognitive functions. A significant cognitive deficit was found at the 2nd week onwards, which persisted up to the 14th week with single and twice ICV-STZ (3 mg/kg) injections, whereas no cognitive impairment was found in ICV-STZ (1 mg/kg) treated groups after 8-10 weeks.
KW - Alzheimer's disease
KW - Morris water maze
KW - cognitive impairment
KW - elevated plus maze
KW - passive avoidance
KW - streptozotocin
UR - http://www.scopus.com/inward/record.url?scp=84872446228&partnerID=8YFLogxK
U2 - 10.3233/JAD-2012-120958
DO - 10.3233/JAD-2012-120958
M3 - Article
AN - SCOPUS:84872446228
SN - 1387-2877
VL - 33
SP - 17
EP - 21
JO - Journal of Alzheimer's Disease
JF - Journal of Alzheimer's Disease
IS - 1
ER -