Streptococcus pneumoniae serotype 11D has a bispecific glycosyltransferase and expresses two different capsular polysaccharide repeating units

Melissa B. Oliver; Chris Jones; Thomas R. Larson; Juan J. Calix; Edward R. Zartler; Janet Yother; Moon H. Nahm

doi:10.1074/jbc.M113.488528

Streptococcus pneumoniae serotype 11D has a bispecific glycosyltransferase and expresses two different capsular polysaccharide repeating units

Melissa B. Oliver
, Chris Jones
, Thomas R. Larson
, Juan J. Calix
, Edward R. Zartler
, Janet Yother
, Moon H. Nahm

Division of Infectious Diseases

Research output: Contribution to journal › Article › peer-review

37 Scopus citations

Abstract

Background: Streptococcus pneumoniae serotype 11D capsular polysaccharide (CPS) structure is unknown. Results: Serotype 11D PS contains two different repeating units; one has αGlcNAc, and the other contains αGlc. Conclusion: The 11D CPS is due to the bispecific glycosyltransferase WcrL. Based on codon 112, WcrL can transfer αGlc, αGlcNAc, or both. Significance: Minimal genetic changes can make bacteria produce different polysaccharides.

Original language	English
Pages (from-to)	21945-21954
Number of pages	10
Journal	Journal of Biological Chemistry
Volume	288
Issue number	30
DOIs	https://doi.org/10.1074/jbc.M113.488528
State	Published - Jul 26 2013

Access to Document

10.1074/jbc.M113.488528

Cite this

@article{48d6ff367aff4901a57fcc08ba3a7d98,

title = "Streptococcus pneumoniae serotype 11D has a bispecific glycosyltransferase and expresses two different capsular polysaccharide repeating units",

abstract = "Background: Streptococcus pneumoniae serotype 11D capsular polysaccharide (CPS) structure is unknown. Results: Serotype 11D PS contains two different repeating units; one has αGlcNAc, and the other contains αGlc. Conclusion: The 11D CPS is due to the bispecific glycosyltransferase WcrL. Based on codon 112, WcrL can transfer αGlc, αGlcNAc, or both. Significance: Minimal genetic changes can make bacteria produce different polysaccharides.",

author = "Oliver, \{Melissa B.\} and Chris Jones and Larson, \{Thomas R.\} and Calix, \{Juan J.\} and Zartler, \{Edward R.\} and Janet Yother and Nahm, \{Moon H.\}",

year = "2013",

month = jul,

day = "26",

doi = "10.1074/jbc.M113.488528",

language = "English",

volume = "288",

pages = "21945--21954",

journal = "Journal of Biological Chemistry",

issn = "0021-9258",

number = "30",

}

TY - JOUR

T1 - Streptococcus pneumoniae serotype 11D has a bispecific glycosyltransferase and expresses two different capsular polysaccharide repeating units

AU - Oliver, Melissa B.

AU - Jones, Chris

AU - Larson, Thomas R.

AU - Calix, Juan J.

AU - Zartler, Edward R.

AU - Yother, Janet

AU - Nahm, Moon H.

PY - 2013/7/26

Y1 - 2013/7/26

N2 - Background: Streptococcus pneumoniae serotype 11D capsular polysaccharide (CPS) structure is unknown. Results: Serotype 11D PS contains two different repeating units; one has αGlcNAc, and the other contains αGlc. Conclusion: The 11D CPS is due to the bispecific glycosyltransferase WcrL. Based on codon 112, WcrL can transfer αGlc, αGlcNAc, or both. Significance: Minimal genetic changes can make bacteria produce different polysaccharides.

AB - Background: Streptococcus pneumoniae serotype 11D capsular polysaccharide (CPS) structure is unknown. Results: Serotype 11D PS contains two different repeating units; one has αGlcNAc, and the other contains αGlc. Conclusion: The 11D CPS is due to the bispecific glycosyltransferase WcrL. Based on codon 112, WcrL can transfer αGlc, αGlcNAc, or both. Significance: Minimal genetic changes can make bacteria produce different polysaccharides.

UR - https://www.scopus.com/pages/publications/84881256665

U2 - 10.1074/jbc.M113.488528

DO - 10.1074/jbc.M113.488528

M3 - Article

C2 - 23737526

AN - SCOPUS:84881256665

SN - 0021-9258

VL - 288

SP - 21945

EP - 21954

JO - Journal of Biological Chemistry

JF - Journal of Biological Chemistry

IS - 30

ER -

Streptococcus pneumoniae serotype 11D has a bispecific glycosyltransferase and expresses two different capsular polysaccharide repeating units

Abstract

Access to Document

Other files and links

Fingerprint

Cite this