Streptococcus pneumoniae serotype 11D has a bispecific glycosyltransferase and expresses two different capsular polysaccharide repeating units

Melissa B. Oliver; Chris Jones; Thomas R. Larson; Juan J. Calix; Edward R. Zartler; Janet Yother; Moon H. Nahm

doi:10.1074/jbc.M113.488528

Streptococcus pneumoniae serotype 11D has a bispecific glycosyltransferase and expresses two different capsular polysaccharide repeating units

Melissa B. Oliver, Chris Jones, Thomas R. Larson, Juan J. Calix, Edward R. Zartler, Janet Yother, Moon H. Nahm

Division of Infectious Diseases

Research output: Contribution to journal › Article › peer-review

36 Scopus citations

Abstract

Background: Streptococcus pneumoniae serotype 11D capsular polysaccharide (CPS) structure is unknown. Results: Serotype 11D PS contains two different repeating units; one has αGlcNAc, and the other contains αGlc. Conclusion: The 11D CPS is due to the bispecific glycosyltransferase WcrL. Based on codon 112, WcrL can transfer αGlc, αGlcNAc, or both. Significance: Minimal genetic changes can make bacteria produce different polysaccharides.

Original language	English
Pages (from-to)	21945-21954
Number of pages	10
Journal	Journal of Biological Chemistry
Volume	288
Issue number	30
DOIs	https://doi.org/10.1074/jbc.M113.488528
State	Published - Jul 26 2013

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title = "Streptococcus pneumoniae serotype 11D has a bispecific glycosyltransferase and expresses two different capsular polysaccharide repeating units",

abstract = "Background: Streptococcus pneumoniae serotype 11D capsular polysaccharide (CPS) structure is unknown. Results: Serotype 11D PS contains two different repeating units; one has αGlcNAc, and the other contains αGlc. Conclusion: The 11D CPS is due to the bispecific glycosyltransferase WcrL. Based on codon 112, WcrL can transfer αGlc, αGlcNAc, or both. Significance: Minimal genetic changes can make bacteria produce different polysaccharides.",

author = "Oliver, {Melissa B.} and Chris Jones and Larson, {Thomas R.} and Calix, {Juan J.} and Zartler, {Edward R.} and Janet Yother and Nahm, {Moon H.}",

year = "2013",

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day = "26",

doi = "10.1074/jbc.M113.488528",

language = "English",

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journal = "Journal of Biological Chemistry",

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TY - JOUR

T1 - Streptococcus pneumoniae serotype 11D has a bispecific glycosyltransferase and expresses two different capsular polysaccharide repeating units

AU - Oliver, Melissa B.

AU - Jones, Chris

AU - Larson, Thomas R.

AU - Calix, Juan J.

AU - Zartler, Edward R.

AU - Yother, Janet

AU - Nahm, Moon H.

PY - 2013/7/26

Y1 - 2013/7/26

N2 - Background: Streptococcus pneumoniae serotype 11D capsular polysaccharide (CPS) structure is unknown. Results: Serotype 11D PS contains two different repeating units; one has αGlcNAc, and the other contains αGlc. Conclusion: The 11D CPS is due to the bispecific glycosyltransferase WcrL. Based on codon 112, WcrL can transfer αGlc, αGlcNAc, or both. Significance: Minimal genetic changes can make bacteria produce different polysaccharides.

AB - Background: Streptococcus pneumoniae serotype 11D capsular polysaccharide (CPS) structure is unknown. Results: Serotype 11D PS contains two different repeating units; one has αGlcNAc, and the other contains αGlc. Conclusion: The 11D CPS is due to the bispecific glycosyltransferase WcrL. Based on codon 112, WcrL can transfer αGlc, αGlcNAc, or both. Significance: Minimal genetic changes can make bacteria produce different polysaccharides.

UR - http://www.scopus.com/inward/record.url?scp=84881256665&partnerID=8YFLogxK

U2 - 10.1074/jbc.M113.488528

DO - 10.1074/jbc.M113.488528

M3 - Article

C2 - 23737526

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SN - 0021-9258

VL - 288

SP - 21945

EP - 21954

JO - Journal of Biological Chemistry

JF - Journal of Biological Chemistry

IS - 30

ER -

Streptococcus pneumoniae serotype 11D has a bispecific glycosyltransferase and expresses two different capsular polysaccharide repeating units

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