Streptococcus pneumoniae serotype 11D has a bispecific glycosyltransferase and expresses two different capsular polysaccharide repeating units

Melissa B. Oliver, Chris Jones, Thomas R. Larson, Juan J. Calix, Edward R. Zartler, Janet Yother, Moon H. Nahm

Research output: Contribution to journalArticlepeer-review

27 Scopus citations

Abstract

Background: Streptococcus pneumoniae serotype 11D capsular polysaccharide (CPS) structure is unknown. Results: Serotype 11D PS contains two different repeating units; one has αGlcNAc, and the other contains αGlc. Conclusion: The 11D CPS is due to the bispecific glycosyltransferase WcrL. Based on codon 112, WcrL can transfer αGlc, αGlcNAc, or both. Significance: Minimal genetic changes can make bacteria produce different polysaccharides.

Original languageEnglish
Pages (from-to)21945-21954
Number of pages10
JournalJournal of Biological Chemistry
Volume288
Issue number30
DOIs
StatePublished - Jul 26 2013

Fingerprint

Dive into the research topics of 'Streptococcus pneumoniae serotype 11D has a bispecific glycosyltransferase and expresses two different capsular polysaccharide repeating units'. Together they form a unique fingerprint.

Cite this