Strategies for developing pH sensitive fluorescent probes

Mikhail Y. Berezin, Kevin Guo, Hyeran Lee, Walter Akers, Adah Almutairi, Jean M.J. Fréchet, Samuel Achilefu

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Scopus citations

Abstract

Many physiological processes function efficiently within a well-controlled pH range. Higher acidity level has been implicated with a number of systemic pathologies. The potential of pH sensitive fluorescent probes for reporting on biological environments has been widely utilized in a variety of cell studies and has been recently recognized as a powerful technique for in vivo imaging of diseases associated with elevated acidity level. We present several strategies for the development of pH sensitive probes suitable for in vivo imaging. The strategies include incorporation of pH sensitive functionalities in known fluorophores, synthesis of novel pH sensitive skeletons, and design of pH sensitive nanoparticles using acid-degradable polymers.

Original languageEnglish
Title of host publicationReporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications II
DOIs
StatePublished - May 10 2010
EventReporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications II - San Francisco, CA, United States
Duration: Jan 25 2010Jan 27 2010

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume7576
ISSN (Print)1605-7422

Conference

ConferenceReporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications II
CountryUnited States
CitySan Francisco, CA
Period01/25/1001/27/10

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    Berezin, M. Y., Guo, K., Lee, H., Akers, W., Almutairi, A., Fréchet, J. M. J., & Achilefu, S. (2010). Strategies for developing pH sensitive fluorescent probes. In Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications II [75760F] (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 7576). https://doi.org/10.1117/12.849452