Strategic plan for lung vascular research: An NHLBI-ORDR Workshop Report

Serpil Erzurum, Sharon I. Rounds, Troy Stevens, Micheala Aldred, Jason Aliotta, Stephen L. Archer, Kewal Asosingh, Robert Balaban, Natalie Bauer, Jahar Bhattacharya, Harm Bogaard, Gaurav Choudhary, Gerald W. Dorn, Raed Dweik, Karen Fagan, Michael Fallon, Toren Finkel, Mark Geraci, Mark T. Gladwin, Paul M. HassounMarc Humbert, Naftali Kaminski, Steven M. Kawut, Joseph Loscalzo, Donald McDonald, Ivan F. McMurtry, John Newman, Mark Nicolls, Marlene Rabinovitch, Judy Shizuru, Masahiko Oka, Peter Polgar, David Rodman, Paul Schumacker, Kurt Stenmark, Rubin Tuder, Norbert Voelkel, Eugene Sullivan, Richard Weinshilboum, Mervin C. Yoder, Yingming Zhao, Dorothy Gail, Timothy M. Moore

Research output: Contribution to journalArticlepeer-review

56 Scopus citations

Abstract

The Division of Lung Diseases of the National Heart, Lung, and Blood Institute, with the Office of Rare Diseases Research, held a workshop to identify priority areas and strategic goals to enhance and accelerate research that will result in improved understanding of the lung vasculature, translational research needs, and ultimately the care of patients with pulmonary vascular diseases. Multidisciplinary experts with diverse experience in laboratory, translational, and clinical studies identified seven priority areas and discussed limitations in our current knowledge, technologies, and approaches. The focus for future research efforts include the following: (1) better characterizing vascular genotype-phenotype relationships and incorporating systems biology approaches when appropriate; (2) advancing our understanding of pulmonary vascular metabolic regulatory signaling in health and disease; (3) expanding our knowledge of the biologic relationships between the lung circulation and circulating elements, systemic vascular function, and right heart function and disease; (4) improving translational research for identifying disease-modifying therapies for the pulmonary hypertensive diseases; (5) establishing an appropriate and effective platform for advancing translational findings into clinical studies testing; and (6) developing the specific technologies and tools that will be enabling for these goals, such as question-guided imaging techniques and lung vascular investigator training programs. Recommendations from this workshop will be used within the Lung Vascular Biology and Disease Extramural Research Programfor planning and strategic implementation purposes.

Original languageEnglish
Pages (from-to)1554-1562
Number of pages9
JournalAmerican journal of respiratory and critical care medicine
Volume182
Issue number12
DOIs
StatePublished - Dec 15 2010

Keywords

  • Genomics
  • Metabolism
  • Phenotyping
  • Pulmonary hypertension
  • Right ventricle

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