Strain-relatedness of methicillin-resistant Staphylococcus aureus isolates recovered from patients with repeated infection

Susan S. Huang, Daniel J. Diekema, David K. Warren, Gianna Zuccotti, Patricia L. Winokur, Shailesh Tendolkar, Linda Boyken, Rupak Datta, Rebecca M. Jones, Melissa A. Ward, Tanya Aubrey, Andrew B. Onderdonk, Christian Garcia, Richard Platt

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Abstract

Invasive disease following methicillin-resistant Staphylococcus aureus (MRSA) detection is common, regardless of whether initial detection involves colonization or infection. We assessed the genetic relatedness of isolates obtained ≥2 weeks apart representing either repeated infections or colonization-infection sets to determine if infections are likely to be caused by previously harbored strains. We found that MRSA infection following initial colonization or infection is caused by the same strain in most cases, suggesting that a single successful attempt at decolonization may prevent the majority of later infection.

Original languageEnglish
Pages (from-to)1241-1247
Number of pages7
JournalClinical Infectious Diseases
Volume46
Issue number8
DOIs
StatePublished - Apr 15 2008

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    Huang, S. S., Diekema, D. J., Warren, D. K., Zuccotti, G., Winokur, P. L., Tendolkar, S., Boyken, L., Datta, R., Jones, R. M., Ward, M. A., Aubrey, T., Onderdonk, A. B., Garcia, C., & Platt, R. (2008). Strain-relatedness of methicillin-resistant Staphylococcus aureus isolates recovered from patients with repeated infection. Clinical Infectious Diseases, 46(8), 1241-1247. https://doi.org/10.1086/529381