Store-operated calcium signaling in neutrophils

Regina A. Clemens, Clifford A. Lowell

Research output: Contribution to journalReview article

34 Scopus citations

Abstract

Calcium signals in neutrophils are initiated by a variety of cell-surface receptors, including formyl peptide and other GPCRs, FcRs, and integrins. The predominant pathway by which calcium enters immune cells is termed SOCE, whereby plasma membrane CRAC channels allow influx of extracellular calcium into the cytoplasm when intracellular ER stores are depleted. The identification of 2 key families of SOCE regulators, STIM calcium “sensors” and ORAI calcium channels, has allowed for genetic manipulation of SOCE pathways and provided valuable insight into the molecular mechanism of calcium signaling in immune cells, including neutrophils. This review focuses on our current knowledge of the molecules involved in neutrophil SOCE and how study of these molecules has further informed our understanding of the role of calcium signaling in neutrophil activation.

Original languageEnglish
Pages (from-to)497-502
Number of pages6
JournalJournal of Leukocyte Biology
Volume98
Issue number4
DOIs
StatePublished - Oct 2015
Externally publishedYes

Keywords

  • Channels
  • NADPH oxidase
  • Neutrophil activation
  • Sensors

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