Abstract

Exposure to monosodium urate crystals (MSU) stimulated the respiratory burst of human neutrophils as measured by increased O2 consumption and the generation of superoxide radicals (O2\documentclass{article}\pagestyle{empty}\begin{document}$ \[\bar .\] $\end{document}). From the comparison of data derived from nitroblue tetrazolium and cytochrome C reduction (two methods of detecting O2\documentclass{article}\pagestyle{empty}\begin{document}$ \[\bar .\] $\end{document} release), it appears that O2\documentclass{article}\pagestyle{empty}\begin{document}$ \[\bar .\] $\end{document} production in response to MSU may be compartmentalized, i.e., occur predominantly in the intracellular space. After exposure to MSU, neutrophils from patients with chronic granulomatous disease lost viability at the normal rate; thus products of the respiratory burst are not likely to be responsible for cell death.

Original languageEnglish
Pages (from-to)181-188
Number of pages8
JournalArthritis & Rheumatism
Volume25
Issue number2
DOIs
StatePublished - Feb 1982

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