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Stimulation of piezo1 by mechanical signals promotes bone anabolism
Xuehua Li
, Li Han
, Intawat Nookaew
, Erin Mannen
,
Matthew J. Silva
, Maria Almeida
, Jinhu Xiong
Department of Orthopedic Surgery
Center of Regenerative Medicine
Roy and Diana Vagelos Division of Biology & Biomedical Sciences (DBBS)
Institute of Clinical and Translational Sciences (ICTS)
Division of Basic Research
DBBS - Molecular Cell Biology
DBBS - Human and Statistical Genetics
Research output
:
Contribution to journal
›
Article
›
peer-review
300
Scopus citations
Overview
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Keyphrases
Adult Mice
16%
Bone Anabolism
100%
Bone Formation
33%
Bone Mass
33%
Bone Matrix
16%
Bone Strength
33%
Bone Therapy
16%
Changes in Gene Expression
16%
Conditional Deletion
16%
Fluid Flow
16%
Fluid Shear Stress
16%
Ion Channels
16%
Mechanical Load
33%
Mechanical Loading
33%
Mechanical Signals
100%
Mechanosensitive Ion Channels
16%
Osteoblast
50%
Osteoblast Lineage Cells
16%
Osteocyte
66%
Piezo1
100%
Sense-and-respond
16%
Small Molecule Agonist
16%
Biochemistry, Genetics and Molecular Biology
Agonist
50%
Anabolism
100%
Bone Mass
50%
Bone Strength
50%
Fluid Flow
25%
Gene Expression
25%
Ion Channel
25%
Mechanosensitive Ion Channel
25%
Ossification
50%
Osteoblast
100%
Osteocyte
100%
Shear Stress
25%
Small Molecule
25%
Medicine and Dentistry
Anabolism
100%
Bone Mass
50%
Bone Matrix
25%
Bone Strength
50%
Gene Expression
25%
Ion Channel
50%
Ossification
50%
Osteoblast
100%
Osteocyte
100%
Immunology and Microbiology
Agonist
50%
Bone Mass
50%
Bone Matrix
25%
Bone Strength
50%
Fluid Flow
25%
Gene Expression
25%
Lineages
25%
Ossification
50%
Osteoblast
100%
Osteocyte
100%
Shear Stress
25%