Stimulation of Intestinal Mucosal Proliferation by Vitamin D

Stanley J. Birge; David H. Alpers

doi:10.1016/S0016-5085(73)80010-1

Stimulation of Intestinal Mucosal Proliferation by Vitamin D

Stanley J. Birge
, David H. Alpers

Division of Gastroenterology

Research output: Contribution to journal › Article › peer-review

47 Scopus citations

Abstract

Intestinal mucosal cell turnover was studied in vitamin D-deficient rats in response to vitamin D₃ repletion. Four hours after a single oral dose of 100 U of vitamin D₃, ³H-thymidine incorporation into deoxyribonucleic acid was enhanced. Mucosal cell migration rate of the vitamin D-repleted animals was 1.5 times that of the deficient animals. The accelerated mucosal cell turnover was associated with an increase of approximately 20% in villus height. This stimulation of mucosal cell proliferation preceded enhanced calcium transport, and, therefore, may be an important component of action of vitamin D on the intestine.

Original language	English
Pages (from-to)	977-982
Number of pages	6
Journal	Gastroenterology
Volume	64
Issue number	5
DOIs	https://doi.org/10.1016/S0016-5085(73)80010-1
State	Published - 1973

Access to Document

10.1016/S0016-5085(73)80010-1

Cite this

@article{21043dcff4bb4244b2307281f9eb567b,

title = "Stimulation of Intestinal Mucosal Proliferation by Vitamin D",

abstract = "Intestinal mucosal cell turnover was studied in vitamin D-deficient rats in response to vitamin D3 repletion. Four hours after a single oral dose of 100 U of vitamin D3, 3H-thymidine incorporation into deoxyribonucleic acid was enhanced. Mucosal cell migration rate of the vitamin D-repleted animals was 1.5 times that of the deficient animals. The accelerated mucosal cell turnover was associated with an increase of approximately 20\% in villus height. This stimulation of mucosal cell proliferation preceded enhanced calcium transport, and, therefore, may be an important component of action of vitamin D on the intestine.",

author = "Birge, \{Stanley J.\} and Alpers, \{David H.\}",

year = "1973",

doi = "10.1016/S0016-5085(73)80010-1",

language = "English",

volume = "64",

pages = "977--982",

journal = "Gastroenterology",

issn = "0016-5085",

number = "5",

}

TY - JOUR

T1 - Stimulation of Intestinal Mucosal Proliferation by Vitamin D

AU - Birge, Stanley J.

AU - Alpers, David H.

PY - 1973

Y1 - 1973

N2 - Intestinal mucosal cell turnover was studied in vitamin D-deficient rats in response to vitamin D3 repletion. Four hours after a single oral dose of 100 U of vitamin D3, 3H-thymidine incorporation into deoxyribonucleic acid was enhanced. Mucosal cell migration rate of the vitamin D-repleted animals was 1.5 times that of the deficient animals. The accelerated mucosal cell turnover was associated with an increase of approximately 20% in villus height. This stimulation of mucosal cell proliferation preceded enhanced calcium transport, and, therefore, may be an important component of action of vitamin D on the intestine.

AB - Intestinal mucosal cell turnover was studied in vitamin D-deficient rats in response to vitamin D3 repletion. Four hours after a single oral dose of 100 U of vitamin D3, 3H-thymidine incorporation into deoxyribonucleic acid was enhanced. Mucosal cell migration rate of the vitamin D-repleted animals was 1.5 times that of the deficient animals. The accelerated mucosal cell turnover was associated with an increase of approximately 20% in villus height. This stimulation of mucosal cell proliferation preceded enhanced calcium transport, and, therefore, may be an important component of action of vitamin D on the intestine.

UR - https://www.scopus.com/pages/publications/0015620751

U2 - 10.1016/S0016-5085(73)80010-1

DO - 10.1016/S0016-5085(73)80010-1

M3 - Article

C2 - 4349476

AN - SCOPUS:0015620751

SN - 0016-5085

VL - 64

SP - 977

EP - 982

JO - Gastroenterology

JF - Gastroenterology

IS - 5

ER -

Stimulation of Intestinal Mucosal Proliferation by Vitamin D

Abstract

Access to Document

Other files and links

Fingerprint

Cite this