Stimulation of Intestinal Mucosal Proliferation by Vitamin D

Stanley J. Birge; David H. Alpers

doi:10.1016/S0016-5085(73)80010-1

Stimulation of Intestinal Mucosal Proliferation by Vitamin D

Stanley J. Birge, David H. Alpers

Division of Gastroenterology

Research output: Contribution to journal › Article › peer-review

46 Scopus citations

Abstract

Intestinal mucosal cell turnover was studied in vitamin D-deficient rats in response to vitamin D₃ repletion. Four hours after a single oral dose of 100 U of vitamin D₃, ³H-thymidine incorporation into deoxyribonucleic acid was enhanced. Mucosal cell migration rate of the vitamin D-repleted animals was 1.5 times that of the deficient animals. The accelerated mucosal cell turnover was associated with an increase of approximately 20% in villus height. This stimulation of mucosal cell proliferation preceded enhanced calcium transport, and, therefore, may be an important component of action of vitamin D on the intestine.

Original language	English
Pages (from-to)	977-982
Number of pages	6
Journal	Gastroenterology
Volume	64
Issue number	5
DOIs	https://doi.org/10.1016/S0016-5085(73)80010-1
State	Published - 1973

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title = "Stimulation of Intestinal Mucosal Proliferation by Vitamin D",

abstract = "Intestinal mucosal cell turnover was studied in vitamin D-deficient rats in response to vitamin D3 repletion. Four hours after a single oral dose of 100 U of vitamin D3, 3H-thymidine incorporation into deoxyribonucleic acid was enhanced. Mucosal cell migration rate of the vitamin D-repleted animals was 1.5 times that of the deficient animals. The accelerated mucosal cell turnover was associated with an increase of approximately 20% in villus height. This stimulation of mucosal cell proliferation preceded enhanced calcium transport, and, therefore, may be an important component of action of vitamin D on the intestine.",

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year = "1973",

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AU - Birge, Stanley J.

AU - Alpers, David H.

PY - 1973

Y1 - 1973

N2 - Intestinal mucosal cell turnover was studied in vitamin D-deficient rats in response to vitamin D3 repletion. Four hours after a single oral dose of 100 U of vitamin D3, 3H-thymidine incorporation into deoxyribonucleic acid was enhanced. Mucosal cell migration rate of the vitamin D-repleted animals was 1.5 times that of the deficient animals. The accelerated mucosal cell turnover was associated with an increase of approximately 20% in villus height. This stimulation of mucosal cell proliferation preceded enhanced calcium transport, and, therefore, may be an important component of action of vitamin D on the intestine.

AB - Intestinal mucosal cell turnover was studied in vitamin D-deficient rats in response to vitamin D3 repletion. Four hours after a single oral dose of 100 U of vitamin D3, 3H-thymidine incorporation into deoxyribonucleic acid was enhanced. Mucosal cell migration rate of the vitamin D-repleted animals was 1.5 times that of the deficient animals. The accelerated mucosal cell turnover was associated with an increase of approximately 20% in villus height. This stimulation of mucosal cell proliferation preceded enhanced calcium transport, and, therefore, may be an important component of action of vitamin D on the intestine.

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JO - Gastroenterology

JF - Gastroenterology

IS - 5

ER -

Stimulation of Intestinal Mucosal Proliferation by Vitamin D

Abstract

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