Stimulation of DNA and collagen synthesis by autologous growth factor in cultured fetal rat calvaria

Ernesto Canalis, William A. Peck, Lawrence G. Raisz

    Research output: Contribution to journalArticlepeer-review

    66 Scopus citations

    Abstract

    Conditioned medium derived from organ or cell cultures prepared from 19- to 21-day fetal rat calvaria stimulated the incorporation of [3H] proline into collagen and of [3H]thymidine into DNA in organ cultures of the same tissue. Addition of cortisol enhanced the effect on collagen but not on DNA synthesis. These effects appeared to be due to a nondialyzable and heat-stable growth factor.

    Original languageEnglish
    Pages (from-to)1021-1023
    Number of pages3
    JournalScience
    Volume210
    Issue number4473
    DOIs
    StatePublished - 1980

    Fingerprint

    Dive into the research topics of 'Stimulation of DNA and collagen synthesis by autologous growth factor in cultured fetal rat calvaria'. Together they form a unique fingerprint.

    Cite this