Stimulation of DNA and collagen synthesis by autologous growth factor in cultured fetal rat calvaria

Ernesto Canalis; William A. Peck; Lawrence G. Raisz

doi:10.1126/science.7434011

Stimulation of DNA and collagen synthesis by autologous growth factor in cultured fetal rat calvaria

Ernesto Canalis, William A. Peck, Lawrence G. Raisz

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66 Scopus citations

Abstract

Conditioned medium derived from organ or cell cultures prepared from 19- to 21-day fetal rat calvaria stimulated the incorporation of [³H] proline into collagen and of [³H]thymidine into DNA in organ cultures of the same tissue. Addition of cortisol enhanced the effect on collagen but not on DNA synthesis. These effects appeared to be due to a nondialyzable and heat-stable growth factor.

Original language	English
Pages (from-to)	1021-1023
Number of pages	3
Journal	Science
Volume	210
Issue number	4473
DOIs	https://doi.org/10.1126/science.7434011
State	Published - 1980

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title = "Stimulation of DNA and collagen synthesis by autologous growth factor in cultured fetal rat calvaria",

abstract = "Conditioned medium derived from organ or cell cultures prepared from 19- to 21-day fetal rat calvaria stimulated the incorporation of [3H] proline into collagen and of [3H]thymidine into DNA in organ cultures of the same tissue. Addition of cortisol enhanced the effect on collagen but not on DNA synthesis. These effects appeared to be due to a nondialyzable and heat-stable growth factor.",

author = "Ernesto Canalis and Peck, {William A.} and Raisz, {Lawrence G.}",

year = "1980",

doi = "10.1126/science.7434011",

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pages = "1021--1023",

journal = "Science",

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T1 - Stimulation of DNA and collagen synthesis by autologous growth factor in cultured fetal rat calvaria

AU - Canalis, Ernesto

AU - Peck, William A.

AU - Raisz, Lawrence G.

PY - 1980

Y1 - 1980

N2 - Conditioned medium derived from organ or cell cultures prepared from 19- to 21-day fetal rat calvaria stimulated the incorporation of [3H] proline into collagen and of [3H]thymidine into DNA in organ cultures of the same tissue. Addition of cortisol enhanced the effect on collagen but not on DNA synthesis. These effects appeared to be due to a nondialyzable and heat-stable growth factor.

AB - Conditioned medium derived from organ or cell cultures prepared from 19- to 21-day fetal rat calvaria stimulated the incorporation of [3H] proline into collagen and of [3H]thymidine into DNA in organ cultures of the same tissue. Addition of cortisol enhanced the effect on collagen but not on DNA synthesis. These effects appeared to be due to a nondialyzable and heat-stable growth factor.

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U2 - 10.1126/science.7434011

DO - 10.1126/science.7434011

M3 - Article

C2 - 7434011

AN - SCOPUS:0019132265

SN - 0036-8075

VL - 210

SP - 1021

EP - 1023

JO - Science

JF - Science

IS - 4473

ER -

Stimulation of DNA and collagen synthesis by autologous growth factor in cultured fetal rat calvaria

Abstract

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