TY - JOUR
T1 - Sticky fibers and uropathogenesis
T2 - bacterial adhesins in the urinary tract.
AU - Wright, Kelly J.
AU - Hultgren, Scott J.
PY - 2006/6
Y1 - 2006/6
N2 - Adhesins mediate the introduction of bacteria to the host in the sometimes life-long relationship of uropathogenic Esherichia coli (UPEC) and the human urinary tract. As a class of extracellular proteins, adhesins enable bacteria to adhere to and, in some cases, invade host tissue; adhesins render UPEC virulent and permit host colonization. Adhesin receptor interactions at the host interface determine tissue tropism and disease progression in that niche, with each adhesin preferring unique sites within the urinary tract. This review focuses on known adhesins implicated in uropathogenesis, the structural basis of tissue tropism, postinvasion intracellular replication, current therapeutic design strategies, and newly discovered fimbrial gene clusters that may play a role in urinary tract infections.
AB - Adhesins mediate the introduction of bacteria to the host in the sometimes life-long relationship of uropathogenic Esherichia coli (UPEC) and the human urinary tract. As a class of extracellular proteins, adhesins enable bacteria to adhere to and, in some cases, invade host tissue; adhesins render UPEC virulent and permit host colonization. Adhesin receptor interactions at the host interface determine tissue tropism and disease progression in that niche, with each adhesin preferring unique sites within the urinary tract. This review focuses on known adhesins implicated in uropathogenesis, the structural basis of tissue tropism, postinvasion intracellular replication, current therapeutic design strategies, and newly discovered fimbrial gene clusters that may play a role in urinary tract infections.
UR - http://www.scopus.com/inward/record.url?scp=34547863207&partnerID=8YFLogxK
U2 - 10.2217/17460913.1.1.75
DO - 10.2217/17460913.1.1.75
M3 - Review article
C2 - 17661687
AN - SCOPUS:34547863207
SN - 1746-0913
VL - 1
SP - 75
EP - 87
JO - Future microbiology
JF - Future microbiology
ER -