TY - JOUR
T1 - Stereotactic body radiotherapy
T2 - A critical review for nonradiation oncologists
AU - Kirkpatrick, John P.
AU - Kelsey, Christopher R.
AU - Palta, Manisha
AU - Cabrera, Alvin R.
AU - Salama, Joseph K.
AU - Patel, Pretesh
AU - Perez, Bradford A.
AU - Lee, Jason
AU - Yin, Fang Fang
PY - 2014/4/1
Y1 - 2014/4/1
N2 - Stereotactic body radiotherapy (SBRT) involves the treatment of extracranial primary tumors or metastases with a few, high doses of ionizing radiation. In SBRT, tumor kill is maximized and dose to surrounding tissue is minimized, by precise and accurate delivery of multiple radiation beams to the target. This is particularly challenging, because extracranial lesions often move with respiration and are irregular in shape, requiring careful treatment planning and continual management of this motion and patient position during irradiation. This review presents the rationale, process workflow, and technology for the safe and effective administration of SBRT, as well as the indications, outcome, and limitations for this technique in the treatment of lung cancer, liver cancer, and metastatic disease.
AB - Stereotactic body radiotherapy (SBRT) involves the treatment of extracranial primary tumors or metastases with a few, high doses of ionizing radiation. In SBRT, tumor kill is maximized and dose to surrounding tissue is minimized, by precise and accurate delivery of multiple radiation beams to the target. This is particularly challenging, because extracranial lesions often move with respiration and are irregular in shape, requiring careful treatment planning and continual management of this motion and patient position during irradiation. This review presents the rationale, process workflow, and technology for the safe and effective administration of SBRT, as well as the indications, outcome, and limitations for this technique in the treatment of lung cancer, liver cancer, and metastatic disease.
KW - intensity-modulated radiotherapy
KW - liver cancer
KW - lung cancer
KW - normal tissue complications
KW - oligometastases
KW - radiosurgery
KW - spine metastases
KW - stereotactic body radiotherapy
UR - http://www.scopus.com/inward/record.url?scp=84899434960&partnerID=8YFLogxK
U2 - 10.1002/cncr.28515
DO - 10.1002/cncr.28515
M3 - Review article
C2 - 24382744
AN - SCOPUS:84899434960
SN - 0008-543X
VL - 120
SP - 942
EP - 954
JO - Cancer
JF - Cancer
IS - 7
ER -