Abstract
(Chemical Equation Presented) A highly stereoselective method for preparing (Z)- and (E)-enol triflates derived from substituted acetoacetate derivatives is described. The salient feature of this methodology is the use of Schotten-Baumann-type conditions to control enolate geometry using either aqueous LiOH (Z-selective) or aqueous (Me)4NOH (E-selective) in combination with triflic anhydride to provide a practical and predictable approach to these valuable substrates.
| Original language | English |
|---|---|
| Pages (from-to) | 2901-2904 |
| Number of pages | 4 |
| Journal | Organic Letters |
| Volume | 10 |
| Issue number | 13 |
| DOIs | |
| State | Published - 2008 |