Stem cell mechanisms and paracrine effects: Potential in cardiac surgery

Paul R. Crisostomo; Meijing Wang; Troy A. Markel; Tim Lahm; Aaron M. Abarbanell; Jeremy L. Herrmann; Daniel R. Meldrum

doi:10.1097/shk.0b013e318058a817

Stem cell mechanisms and paracrine effects: Potential in cardiac surgery

Paul R. Crisostomo, Meijing Wang, Troy A. Markel, Tim Lahm, Aaron M. Abarbanell, Jeremy L. Herrmann, Daniel R. Meldrum

Research output: Contribution to journal › Review article › peer-review

58 Scopus citations

Abstract

Heart disease remains the leading cause of death in the industrialized world. Stem cell therapy is a promising treatment modality for injured cardiac tissue. A novel mechanism for this cardioprotection may include paracrine actions. Cardiac surgery represents the unique situation where preischemia and postischemia treatment modalities exist that may use stem cell paracrine protection. This review (1) recalls the history of stem cells in cardiac disease and the unraveling of its mechanistic basis for protection, (2) outlines the pathways for stem cell-mediated paracrine protection, (3) highlights the signaling factors expressed, (4) explores the potential of using stem cells clinically in cardiac surgery, and (5) summarizes all human stem cell studies in cardiac disease to date.

Original language	English
Pages (from-to)	375-383
Number of pages	9
Journal	Shock
Volume	28
Issue number	4
DOIs	https://doi.org/10.1097/shk.0b013e318058a817
State	Published - Oct 2007
Externally published	Yes

Keywords

Cardioprotection
HGF
MSC
Mesenchymal
Signaling
VEGF

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10.1097/shk.0b013e318058a817

Cite this

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title = "Stem cell mechanisms and paracrine effects: Potential in cardiac surgery",

abstract = "Heart disease remains the leading cause of death in the industrialized world. Stem cell therapy is a promising treatment modality for injured cardiac tissue. A novel mechanism for this cardioprotection may include paracrine actions. Cardiac surgery represents the unique situation where preischemia and postischemia treatment modalities exist that may use stem cell paracrine protection. This review (1) recalls the history of stem cells in cardiac disease and the unraveling of its mechanistic basis for protection, (2) outlines the pathways for stem cell-mediated paracrine protection, (3) highlights the signaling factors expressed, (4) explores the potential of using stem cells clinically in cardiac surgery, and (5) summarizes all human stem cell studies in cardiac disease to date.",

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AU - Crisostomo, Paul R.

AU - Wang, Meijing

AU - Markel, Troy A.

AU - Lahm, Tim

AU - Abarbanell, Aaron M.

AU - Herrmann, Jeremy L.

AU - Meldrum, Daniel R.

PY - 2007/10

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AB - Heart disease remains the leading cause of death in the industrialized world. Stem cell therapy is a promising treatment modality for injured cardiac tissue. A novel mechanism for this cardioprotection may include paracrine actions. Cardiac surgery represents the unique situation where preischemia and postischemia treatment modalities exist that may use stem cell paracrine protection. This review (1) recalls the history of stem cells in cardiac disease and the unraveling of its mechanistic basis for protection, (2) outlines the pathways for stem cell-mediated paracrine protection, (3) highlights the signaling factors expressed, (4) explores the potential of using stem cells clinically in cardiac surgery, and (5) summarizes all human stem cell studies in cardiac disease to date.

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KW - Mesenchymal

KW - Signaling

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Stem cell mechanisms and paracrine effects: Potential in cardiac surgery

Abstract

Keywords

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