TY - JOUR
T1 - Stem cell-based therapies for osteoarthritis
T2 - Challenges and opportunities
AU - Diekman, Brian O.
AU - Guilak, Farshid
PY - 2013/1
Y1 - 2013/1
N2 - Purpose of Review: Regenerative medicine offers the exciting potential of developing alternatives to total joint replacement for treating osteoarthritis. In this article, we highlight recent work that addresses key challenges of stem cell-based therapies for osteoarthritis and provide examples of innovative ways in which stem cells can aid in the treatment of osteoarthritis. Recent Findings: Significant progress has been made in understanding the challenges to successful stem cell therapy, such as the effects of age or disease on stem cell properties, altered stem cell function due to an inflammatory joint environment and phenotypic instability in vivo. Novel scaffold designs have been shown to enhance the mechanical properties of tissue-engineered cartilage and have also improved the integration of newly formed tissue within the joint. Emerging strategies such as injecting stem cells directly into the joint, manipulating endogenous stem cells to enhance regenerative capacity and utilizing stem cells for drug discovery have expanded the potential uses of stem cells in treating osteoarthritis. Summary: Several recent studies have greatly advanced the development and preclinical evaluation of potential stem cell-based treatments for osteoarthritis through novel approaches focused on cell therapy, tissue engineering and drug discovery.
AB - Purpose of Review: Regenerative medicine offers the exciting potential of developing alternatives to total joint replacement for treating osteoarthritis. In this article, we highlight recent work that addresses key challenges of stem cell-based therapies for osteoarthritis and provide examples of innovative ways in which stem cells can aid in the treatment of osteoarthritis. Recent Findings: Significant progress has been made in understanding the challenges to successful stem cell therapy, such as the effects of age or disease on stem cell properties, altered stem cell function due to an inflammatory joint environment and phenotypic instability in vivo. Novel scaffold designs have been shown to enhance the mechanical properties of tissue-engineered cartilage and have also improved the integration of newly formed tissue within the joint. Emerging strategies such as injecting stem cells directly into the joint, manipulating endogenous stem cells to enhance regenerative capacity and utilizing stem cells for drug discovery have expanded the potential uses of stem cells in treating osteoarthritis. Summary: Several recent studies have greatly advanced the development and preclinical evaluation of potential stem cell-based treatments for osteoarthritis through novel approaches focused on cell therapy, tissue engineering and drug discovery.
KW - Arthritis
KW - induced pluripotent stem cells
KW - inflammation
KW - mesenchymal stem cells
KW - tissue engineering
UR - http://www.scopus.com/inward/record.url?scp=84871250440&partnerID=8YFLogxK
U2 - 10.1097/BOR.0b013e32835aa28d
DO - 10.1097/BOR.0b013e32835aa28d
M3 - Review article
C2 - 23190869
AN - SCOPUS:84871250440
SN - 1040-8711
VL - 25
SP - 119
EP - 126
JO - Current opinion in rheumatology
JF - Current opinion in rheumatology
IS - 1
ER -