TY - JOUR
T1 - Stem and Progenitor Cells for Cartilage Repair
T2 - Source, Safety, Evidence, and Efficacy
AU - Rodriguez-Fontan, Francisco
AU - Piuzzi, Nicolas S.
AU - Chahla, Jorge
AU - Payne, Karin A.
AU - LaPrade, Robert F.
AU - Muschler, George F.
AU - Pascual-Garrido, Cecilia
N1 - Publisher Copyright:
© 2017 Elsevier Inc.
Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 2017/3/1
Y1 - 2017/3/1
N2 - Cartilage is a sensitive tissue prone to damage with sports and aging. Degenerative joint diseases are among the most profound in limiting quality of life and daily activities. Biological therapies have become available to potentially treat osteoarthritis and focal chondral defects. However, there remains no efficient way to regenerate native hyaline cartilage. Stem cell therapy and bioengineering constitute a promising field, which may transform our paradigms in orthopaedics. This article provides an overview of the current status and efficacy of stem and progenitor cell therapies that include cultured and nonexpanded sources such as bone marrow, adipose tissue, synovium, and peripheral blood. The purpose of this article is to summarize the reported potential of adult stem cell therapies focusing on focal chondral defects and osteoarthritis.
AB - Cartilage is a sensitive tissue prone to damage with sports and aging. Degenerative joint diseases are among the most profound in limiting quality of life and daily activities. Biological therapies have become available to potentially treat osteoarthritis and focal chondral defects. However, there remains no efficient way to regenerate native hyaline cartilage. Stem cell therapy and bioengineering constitute a promising field, which may transform our paradigms in orthopaedics. This article provides an overview of the current status and efficacy of stem and progenitor cell therapies that include cultured and nonexpanded sources such as bone marrow, adipose tissue, synovium, and peripheral blood. The purpose of this article is to summarize the reported potential of adult stem cell therapies focusing on focal chondral defects and osteoarthritis.
KW - biologics
KW - cartilage
KW - focal chondral lesions
KW - osteoarthritis
KW - progenitor cells
KW - stem cells
UR - http://www.scopus.com/inward/record.url?scp=85013096146&partnerID=8YFLogxK
U2 - 10.1053/j.otsm.2016.12.005
DO - 10.1053/j.otsm.2016.12.005
M3 - Article
AN - SCOPUS:85013096146
SN - 1060-1872
VL - 25
SP - 25
EP - 33
JO - Operative Techniques in Sports Medicine
JF - Operative Techniques in Sports Medicine
IS - 1
ER -