TY - JOUR
T1 - Staying awake to stay alive
T2 - A circuit controlling starvation-induced waking
AU - Melnattur, Krishna
AU - Shaw, Paul
N1 - Publisher Copyright:
© 2019 Melnattur, Shaw.
PY - 2019/3
Y1 - 2019/3
N2 - The balance of sleep and wake is plastic and changes to meet environmental demands. Mechanisms that allow an animal to suppress sleep and maintain waking in potentially adverse situations could serve adaptive functions in evolution. The fruit fly, Drosophila melanogaster, is well poised as a system in which to explore these questions. The environment changes sleep and wake in flies, e.g., starvation induces waking in Drosophila as it does in many animals. Further, the sophisticated neurobiological toolkit available to Drosophila researchers gives the fly a great advantage as a system to investigate the precise neurobiological mechanisms underlying these adaptive changes. In a paper in this issue of PLOS Biology, Yurgel and colleagues elegantly exploit the advantages of the Drosophila model to map starvation-induced wakefulness to a single pair of peptidergic neurons and their partners.
AB - The balance of sleep and wake is plastic and changes to meet environmental demands. Mechanisms that allow an animal to suppress sleep and maintain waking in potentially adverse situations could serve adaptive functions in evolution. The fruit fly, Drosophila melanogaster, is well poised as a system in which to explore these questions. The environment changes sleep and wake in flies, e.g., starvation induces waking in Drosophila as it does in many animals. Further, the sophisticated neurobiological toolkit available to Drosophila researchers gives the fly a great advantage as a system to investigate the precise neurobiological mechanisms underlying these adaptive changes. In a paper in this issue of PLOS Biology, Yurgel and colleagues elegantly exploit the advantages of the Drosophila model to map starvation-induced wakefulness to a single pair of peptidergic neurons and their partners.
UR - http://www.scopus.com/inward/record.url?scp=85064579297&partnerID=8YFLogxK
U2 - 10.1371/journal.pbio.3000199
DO - 10.1371/journal.pbio.3000199
M3 - Article
C2 - 30917116
AN - SCOPUS:85064579297
SN - 1544-9173
VL - 17
JO - PLoS biology
JF - PLoS biology
IS - 3
M1 - e3000199
ER -