TY - JOUR
T1 - Statoviruses, A novel taxon of RNA viruses present in the gastrointestinal tracts of diverse mammals
AU - Janowski, Andrew B.
AU - Krishnamurthy, Siddharth R.
AU - Lim, Efrem S.
AU - Zhao, Guoyan
AU - Brenchley, Jason M.
AU - Barouch, Dan H.
AU - Thakwalakwa, Chrissie
AU - Manary, Mark J.
AU - Holtz, Lori R.
AU - Wang, David
N1 - Funding Information:
ABJ is supported in part by the NIH under the training grant NIH T32 AI106688. SRK is supported in part by the NIH under the training grant T32 AI 007172. ESL is an Eli and Edythe Broad Fellow of the Life Sciences Research Foundation and is supported by NIH grant K99 DK107923. MJM holds grants from the Bill and Melinda Gates Foundation and the Children's Discovery Institute MD-LI-2013-335. LRH holds a grant from the Children's Discovery Institute MD-FR-2013-292. D.W. holds an Investigator in the Pathogenesis of Infectious Disease award from the Burroughs Welcome Fund.
Publisher Copyright:
© 2017 The Authors
PY - 2017/4/1
Y1 - 2017/4/1
N2 - Next-generation sequencing has expanded our understanding of the viral populations that constitute the mammalian virome. We describe a novel taxon of viruses named Statoviruses, for Stool associated Tombus-like viruses, present in multiple metagenomic datasets. These viruses define a novel clade that is phylogenetically related to the RNA virus families Tombusviridae and Flaviviridae. Five distinct statovirus types were identified in human, macaque, mouse, and cow gastrointestinal tract samples. The prototype genome, statovirus A, was frequently identified in macaque stool samples from multiple geographically distinct cohorts. Another genome, statovirus C1, was discovered in a stool sample from a human child with fever, cough, and rash. Further experimental data will clarify whether these viruses are infectious to mammals or if they originate from another source present in the mammalian gastrointestinal tract.
AB - Next-generation sequencing has expanded our understanding of the viral populations that constitute the mammalian virome. We describe a novel taxon of viruses named Statoviruses, for Stool associated Tombus-like viruses, present in multiple metagenomic datasets. These viruses define a novel clade that is phylogenetically related to the RNA virus families Tombusviridae and Flaviviridae. Five distinct statovirus types were identified in human, macaque, mouse, and cow gastrointestinal tract samples. The prototype genome, statovirus A, was frequently identified in macaque stool samples from multiple geographically distinct cohorts. Another genome, statovirus C1, was discovered in a stool sample from a human child with fever, cough, and rash. Further experimental data will clarify whether these viruses are infectious to mammals or if they originate from another source present in the mammalian gastrointestinal tract.
KW - Flaviviridae
KW - Statoviruses
KW - Tombusviridae
KW - Viral discovery
KW - Virome
UR - http://www.scopus.com/inward/record.url?scp=85012307227&partnerID=8YFLogxK
U2 - 10.1016/j.virol.2017.01.010
DO - 10.1016/j.virol.2017.01.010
M3 - Article
C2 - 28152382
AN - SCOPUS:85012307227
SN - 0042-6822
VL - 504
SP - 36
EP - 44
JO - Virology
JF - Virology
ER -