TY - JOUR
T1 - Statistical issues in the analysis of DNA Copy Number Variations.
AU - Wineinger, Nathan E.
AU - Kennedy, Richard E.
AU - Erickson, Stephen W.
AU - Wojczynski, Mary K.
AU - Bruder, Carl E.
AU - Tiwari, Hemant K.
PY - 2008
Y1 - 2008
N2 - Approaches to assess copy number variation have advanced rapidly and are being incorporated into genetic studies. While the technology exists for CNV genotyping, a further understanding and discussion of how to use the CNV data for association analyses is warranted. We present the options available for processing and analysing CNV data. We break these steps down into choice of genotyping platform, normalisation of the array data, calling algorithm, and statistical analysis.
AB - Approaches to assess copy number variation have advanced rapidly and are being incorporated into genetic studies. While the technology exists for CNV genotyping, a further understanding and discussion of how to use the CNV data for association analyses is warranted. We present the options available for processing and analysing CNV data. We break these steps down into choice of genotyping platform, normalisation of the array data, calling algorithm, and statistical analysis.
UR - http://www.scopus.com/inward/record.url?scp=77949890563&partnerID=8YFLogxK
U2 - 10.1504/IJCBDD.2008.022208
DO - 10.1504/IJCBDD.2008.022208
M3 - Review article
C2 - 19774103
AN - SCOPUS:77949890563
SN - 1756-0756
VL - 1
SP - 368
EP - 395
JO - International journal of computational biology and drug design
JF - International journal of computational biology and drug design
IS - 4
ER -