Statistical issues in the analysis of DNA Copy Number Variations.

Nathan E. Wineinger, Richard E. Kennedy, Stephen W. Erickson, Mary K. Wojczynski, Carl E. Bruder, Hemant K. Tiwari

Research output: Contribution to journalReview articlepeer-review

19 Scopus citations


Approaches to assess copy number variation have advanced rapidly and are being incorporated into genetic studies. While the technology exists for CNV genotyping, a further understanding and discussion of how to use the CNV data for association analyses is warranted. We present the options available for processing and analysing CNV data. We break these steps down into choice of genotyping platform, normalisation of the array data, calling algorithm, and statistical analysis.

Original languageEnglish
Pages (from-to)368-395
Number of pages28
JournalInternational journal of computational biology and drug design
Issue number4
StatePublished - 2008


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