The biological response of the meniscus to static compression was quantified as changes in gene expression levels for relevant extracellular matrix proteins. Decreased mRNA levels for decorin and type I collagen were observed, as well as increased mRNA levels for the matrix metalloproteinase MMP-1. These findings demonstrate that the response of the meniscus to mechanical stimuli may be regulated in part at the transcriptional level.

Original languageEnglish
Pages (from-to)438-439
Number of pages2
JournalAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
StatePublished - Dec 1 2002
EventProceedings of the 2002 IEEE Engineering in Medicine and Biology 24th Annual Conference and the 2002 Fall Meeting of the Biomedical Engineering Society (BMES / EMBS) - Houston, TX, United States
Duration: Oct 23 2002Oct 26 2002


  • Compression
  • Gene expression
  • Meniscus


Dive into the research topics of 'Static compression inhibits matrix protein gene expression and increases collagenase gene expression in the meniscus'. Together they form a unique fingerprint.

Cite this