The biological response of the meniscus to static compression was quantified as changes in gene expression levels for relevant extracellular matrix proteins. Decreased mRNA levels for decorin and type I collagen were observed, as well as increased mRNA levels for the matrix metalloproteinase MMP-1. These findings demonstrate that the response of the meniscus to mechanical stimuli may be regulated in part at the transcriptional level.
|Number of pages||2|
|Journal||Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings|
|State||Published - Dec 1 2002|
|Event||Proceedings of the 2002 IEEE Engineering in Medicine and Biology 24th Annual Conference and the 2002 Fall Meeting of the Biomedical Engineering Society (BMES / EMBS) - Houston, TX, United States|
Duration: Oct 23 2002 → Oct 26 2002
- Gene expression