Static compression inhibits matrix protein gene expression and increases collagenase gene expression in the meniscus

M. L. Upton; J. Chen; F. Guilak; L. A. Setton

Static compression inhibits matrix protein gene expression and increases collagenase gene expression in the meniscus

M. L. Upton, J. Chen, F. Guilak, L. A. Setton

Research output: Contribution to journal › Conference article › peer-review

Abstract

The biological response of the meniscus to static compression was quantified as changes in gene expression levels for relevant extracellular matrix proteins. Decreased mRNA levels for decorin and type I collagen were observed, as well as increased mRNA levels for the matrix metalloproteinase MMP-1. These findings demonstrate that the response of the meniscus to mechanical stimuli may be regulated in part at the transcriptional level.

Original language	English
Pages (from-to)	438-439
Number of pages	2
Journal	Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
Volume	1
State	Published - Dec 1 2002
Event	Proceedings of the 2002 IEEE Engineering in Medicine and Biology 24th Annual Conference and the 2002 Fall Meeting of the Biomedical Engineering Society (BMES / EMBS) - Houston, TX, United States Duration: Oct 23 2002 → Oct 26 2002

Keywords

Compression
Gene expression
Meniscus

Cite this

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title = "Static compression inhibits matrix protein gene expression and increases collagenase gene expression in the meniscus",

abstract = "The biological response of the meniscus to static compression was quantified as changes in gene expression levels for relevant extracellular matrix proteins. Decreased mRNA levels for decorin and type I collagen were observed, as well as increased mRNA levels for the matrix metalloproteinase MMP-1. These findings demonstrate that the response of the meniscus to mechanical stimuli may be regulated in part at the transcriptional level.",

keywords = "Compression, Gene expression, Meniscus",

author = "Upton, {M. L.} and J. Chen and F. Guilak and Setton, {L. A.}",

year = "2002",

month = dec,

day = "1",

language = "English",

volume = "1",

pages = "438--439",

journal = "Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings",

issn = "0589-1019",

note = "null ; Conference date: 23-10-2002 Through 26-10-2002",

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Static compression inhibits matrix protein gene expression and increases collagenase gene expression in the meniscus. / Upton, M. L.; Chen, J.; Guilak, F. et al.

In: Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings, Vol. 1, 01.12.2002, p. 438-439.

Research output: Contribution to journal › Conference article › peer-review

TY - JOUR

T1 - Static compression inhibits matrix protein gene expression and increases collagenase gene expression in the meniscus

AU - Upton, M. L.

AU - Chen, J.

AU - Guilak, F.

AU - Setton, L. A.

PY - 2002/12/1

Y1 - 2002/12/1

N2 - The biological response of the meniscus to static compression was quantified as changes in gene expression levels for relevant extracellular matrix proteins. Decreased mRNA levels for decorin and type I collagen were observed, as well as increased mRNA levels for the matrix metalloproteinase MMP-1. These findings demonstrate that the response of the meniscus to mechanical stimuli may be regulated in part at the transcriptional level.

AB - The biological response of the meniscus to static compression was quantified as changes in gene expression levels for relevant extracellular matrix proteins. Decreased mRNA levels for decorin and type I collagen were observed, as well as increased mRNA levels for the matrix metalloproteinase MMP-1. These findings demonstrate that the response of the meniscus to mechanical stimuli may be regulated in part at the transcriptional level.

KW - Compression

KW - Gene expression

KW - Meniscus

UR - http://www.scopus.com/inward/record.url?scp=0036907733&partnerID=8YFLogxK

M3 - Conference article

AN - SCOPUS:0036907733

SN - 0589-1019

VL - 1

SP - 438

EP - 439

JO - Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings

JF - Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings

Y2 - 23 October 2002 through 26 October 2002

ER -

Static compression inhibits matrix protein gene expression and increases collagenase gene expression in the meniscus

Abstract

Keywords

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