Static compression inhibits matrix protein gene expression and increases collagenase gene expression in the meniscus

M. L. Upton, J. Chen, F. Guilak, L. A. Setton

Research output: Contribution to journalConference article

Abstract

The biological response of the meniscus to static compression was quantified as changes in gene expression levels for relevant extracellular matrix proteins. Decreased mRNA levels for decorin and type I collagen were observed, as well as increased mRNA levels for the matrix metalloproteinase MMP-1. These findings demonstrate that the response of the meniscus to mechanical stimuli may be regulated in part at the transcriptional level.

Original languageEnglish
Pages (from-to)438-439
Number of pages2
JournalAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
Volume1
StatePublished - Dec 1 2002
Externally publishedYes
EventProceedings of the 2002 IEEE Engineering in Medicine and Biology 24th Annual Conference and the 2002 Fall Meeting of the Biomedical Engineering Society (BMES / EMBS) - Houston, TX, United States
Duration: Oct 23 2002Oct 26 2002

Keywords

  • Compression
  • Gene expression
  • Meniscus

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