State of the art: The hypereosinophilic syndromes

J. L. Liesveld, C. N. Abboud

Research output: Contribution to journalArticlepeer-review

33 Scopus citations


Many disease states such as parasitic infestations, malignancies, collagen vascular diseases, and allergies are associated with eosinophilia. The diagnosis of idiopathic hypereosinophilic syndrome (HES) requires a persistent elevation in the total eosinophil count (> 1500/mm3) for over 6 months, associated organ damage and no detectable underlying cause. This review provides an updated summary of the cytokine cascade that controls eosinophil production and delineates our current understanding of the clinical features of hypereosinophilic states. We also examine the central role of T-lymphocyte activation in eosinophilia, and have attempted to integrate current treatment strategies for HES with the physiology of eosinophilopoiesis.

Original languageEnglish
Pages (from-to)29-37
Number of pages9
JournalBlood Reviews
Issue number1
StatePublished - Mar 1991


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