State-of-the-Art Imaging of Infiltrative Cardiomyopathies: A Scientific Statement from the American Heart Association

Anupama Kottam, Kate Hanneman, Aldo Schenone, Melissa A. Daubert, Gursukhman Deep Sidhu, Robert J. Gropler, Mario J. Garcia

Research output: Contribution to journalReview articlepeer-review


Infiltrative cardiomyopathies comprise a broad spectrum of inherited or acquired conditions caused by deposition of abnormal substances within the myocardium. Increased wall thickness, inflammation, microvascular dysfunction, and fibrosis are the common pathological processes that lead to abnormal myocardial filling, chamber dilation, and disruption of conduction system. Advanced disease presents as heart failure and cardiac arrhythmias conferring poor prognosis. Infiltrative cardiomyopathies are often diagnosed late or misclassified as other more common conditions, such as hypertrophic cardiomyopathy, hypertensive heart disease, ischemic or other forms of nonischemic cardiomyopathies. Accurate diagnosis is also critical because clinical features, testing methodologies, and approach to treatment vary significantly even within the different types of infiltrative cardiomyopathies on the basis of the type of substance deposited. Substantial advances in noninvasive cardiac imaging have enabled accurate and early diagnosis. thereby eliminating the need for endomyocardial biopsy in most cases. This scientific statement discusses the role of contemporary multimodality imaging of infiltrative cardiomyopathies, including echocardiography, nuclear and cardiac magnetic resonance imaging in the diagnosis, prognostication, and assessment of response to treatment.

Original languageEnglish
Pages (from-to)E000081
JournalCirculation: Cardiovascular Imaging
Issue number11
StatePublished - Nov 1 2023


  • AHA Scientific Statements
  • arrhythmias, cardiac
  • cardiomyopathies
  • echocardiography
  • heart failure
  • magnetic resonance imaging
  • radionuclide imaging


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