STAT1-dependent innate immunity to a norwalk-like virus

Stephanie M. Karst, Christiane E. Wobus, Margarita Lay, John Davidson, Herbert W. Virgin IV

Research output: Contribution to journalArticlepeer-review

639 Scopus citations

Abstract

Norwalk-like caliciviruses (Noroviruses) cause over 90% of nonbacterial epidemic gastroenteritis worldwide, but the pathogenesis of norovirus infection is poorly understood because these viruses do not grow in cultured cells and there is no small animal model. Here, we report a previously unknown murine norovirus. Analysis of Murine Norovirus 1 infection revealed that signal transducer and activator of transcription 1-dependent innate immunity, but not T and B cell-dependent adaptive immunity, is essential for norovirus resistance. The identification of host molecules essential for murine norovirus resistance may provide targets for prevention or control of an important human disease.

Original languageEnglish
Pages (from-to)1575-1578
Number of pages4
JournalScience
Volume299
Issue number5612
DOIs
StatePublished - Mar 7 2003

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