TY - JOUR
T1 - STAT1-dependent innate immunity to a norwalk-like virus
AU - Karst, Stephanie M.
AU - Wobus, Christiane E.
AU - Lay, Margarita
AU - Davidson, John
AU - Virgin IV, Herbert W.
PY - 2003/3/7
Y1 - 2003/3/7
N2 - Norwalk-like caliciviruses (Noroviruses) cause over 90% of nonbacterial epidemic gastroenteritis worldwide, but the pathogenesis of norovirus infection is poorly understood because these viruses do not grow in cultured cells and there is no small animal model. Here, we report a previously unknown murine norovirus. Analysis of Murine Norovirus 1 infection revealed that signal transducer and activator of transcription 1-dependent innate immunity, but not T and B cell-dependent adaptive immunity, is essential for norovirus resistance. The identification of host molecules essential for murine norovirus resistance may provide targets for prevention or control of an important human disease.
AB - Norwalk-like caliciviruses (Noroviruses) cause over 90% of nonbacterial epidemic gastroenteritis worldwide, but the pathogenesis of norovirus infection is poorly understood because these viruses do not grow in cultured cells and there is no small animal model. Here, we report a previously unknown murine norovirus. Analysis of Murine Norovirus 1 infection revealed that signal transducer and activator of transcription 1-dependent innate immunity, but not T and B cell-dependent adaptive immunity, is essential for norovirus resistance. The identification of host molecules essential for murine norovirus resistance may provide targets for prevention or control of an important human disease.
UR - http://www.scopus.com/inward/record.url?scp=0037423838&partnerID=8YFLogxK
U2 - 10.1126/science.1077905
DO - 10.1126/science.1077905
M3 - Article
C2 - 12624267
AN - SCOPUS:0037423838
SN - 0036-8075
VL - 299
SP - 1575
EP - 1578
JO - Science
JF - Science
IS - 5612
ER -