TY - JOUR
T1 - Stat1-dependent and -independent pathways in IFN-γ-dependent signaling
AU - Ramana, Chilakamarti V.
AU - Gil, M. Pilar
AU - Schreiber, Robert D.
AU - Stark, George R.
PY - 2002/2/1
Y1 - 2002/2/1
N2 - The paradigm that emerged from studies during the past decade established a central role for Jak-Stat (signal transducer and activator of transcription) signaling pathways in promoting the diverse cellular responses induced by interferon γ (IFN-γ). However, recent studies have shown that the IFN-γ receptor activates additional signaling pathways and can regulate gene expression by Stat1-independent pathways. The diversity of gene-expression patterns mediated by Stat1-dependent and -independent mechanisms and the balance between these two pathways play an important role in the biological response to IFN-γ.
AB - The paradigm that emerged from studies during the past decade established a central role for Jak-Stat (signal transducer and activator of transcription) signaling pathways in promoting the diverse cellular responses induced by interferon γ (IFN-γ). However, recent studies have shown that the IFN-γ receptor activates additional signaling pathways and can regulate gene expression by Stat1-independent pathways. The diversity of gene-expression patterns mediated by Stat1-dependent and -independent mechanisms and the balance between these two pathways play an important role in the biological response to IFN-γ.
UR - http://www.scopus.com/inward/record.url?scp=0036476551&partnerID=8YFLogxK
U2 - 10.1016/S1471-4906(01)02118-4
DO - 10.1016/S1471-4906(01)02118-4
M3 - Review article
C2 - 11929133
AN - SCOPUS:0036476551
SN - 1471-4906
VL - 23
SP - 96
EP - 101
JO - Trends in Immunology
JF - Trends in Immunology
IS - 2
ER -