Stat1-dependent and -independent pathways in IFN-γ-dependent signaling

Chilakamarti V. Ramana, M. Pilar Gil, Robert D. Schreiber, George R. Stark

Research output: Contribution to journalReview articlepeer-review

463 Scopus citations


The paradigm that emerged from studies during the past decade established a central role for Jak-Stat (signal transducer and activator of transcription) signaling pathways in promoting the diverse cellular responses induced by interferon γ (IFN-γ). However, recent studies have shown that the IFN-γ receptor activates additional signaling pathways and can regulate gene expression by Stat1-independent pathways. The diversity of gene-expression patterns mediated by Stat1-dependent and -independent mechanisms and the balance between these two pathways play an important role in the biological response to IFN-γ.

Original languageEnglish
Pages (from-to)96-101
Number of pages6
JournalTrends in Immunology
Issue number2
StatePublished - Feb 1 2002


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