Stat-1 is not essential for inhibition of B lymphopoiesis by type I IFNs

R. Gongora, R. P. Stephan, R. D. Schreiber, M. D. Cooper

Research output: Contribution to journalArticlepeer-review

28 Scopus citations


Type I IFNs, IFN-α, -β, and -ω, are cytokine family members with multiple immune response roles, including the promotion of cell growth and differentiation. Conversely, the type I IFNs are potent inhibitors of IL-7-dependent growth of early B lineage progenitors, effectively aborting further B lineage differentiation at the pro. B cell stage. Type I IFNs α and β function via receptor-mediated activation of a Jak/Stat signaling pathway in which Stat-1 is functionally important, because many IFN-induced responses are abrogated in Stat-1-deficient mice. To the contrary, we show here that the inhibition of IL-7-dependent B lymphopoiesis by IFN-αβ is unaffected in Stat-1-deficient mice. The present data indicate that the type I IFNs can activate an alternative signaling pathway in which neither Stat-1 nor phosphatidylinositol 3'-kinase are essential components.

Original languageEnglish
Pages (from-to)2362-2366
Number of pages5
JournalJournal of Immunology
Issue number5
StatePublished - Sep 1 2000


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